Prednisolone and Levoxyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prednisolone (prednisolone) and Levoxyl (levothyroxine sodium). Common drug interactions include haematocrit increased among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Prednisolone and Levoxyl. It is created by eHealthMe based on reports of 71 people who take the same drugs from the FDA, and is updated regularly.

What is Prednisolone?

Prednisolone has active ingredients of prednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 212,675 Prednisolone users. Check the latest studies of Prednisolone.

What is Levoxyl?

Levoxyl has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 25,178 Levoxyl users. Check the latest studies of Levoxyl.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

71 people who take Prednisolone and Levoxyl together, and have interactions are studied.

Prednisolone and Levoxyl drug interactions.

What are the common drug interactions of Prednisolone and Levoxyl, by gender? *:

female:

Haematocrit increased
Hepatic cyst
Humerus fracture (injury to the upper arm bone)
Infected dermal cyst
Intervertebral disc protrusion (spinal disc protrusion)
Ligament rupture (tear in ligament)
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Metastases to liver (cancer spreads to liver)
Metastases to spine (cancer spreads to spine)
Metastases to thorax (cancer spreads to thorax)

male:

Asthenia (weakness)
Pain
Chills (felling of cold)
Complication of device insertion
Constipation
Cough
Cytomegalovirus infection
Diarrhoea
Ear infection
Facial spasm (involuntary muscle contractions face)

What are the common drug interactions of Prednisolone and Levoxyl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Diarrhoea
Pyrexia (fever)
Abdominal pain upper
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Adjustment disorder
Alopecia (absence of hair from areas of the body)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Arthralgia (joint pain)
Asthenia (weakness)

40-49:

Anxiety
Depression
Back pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Constipation
Dysuria (painful or difficult urination)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Nausea (feeling of having an urge to vomit)
Osteonecrosis of jaw (death of bone of jaw)
Pain

50-59:

Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Dehydration (dryness resulting from the removal of water)
Depression
Foot fracture
Glycosuria (excretion of glucose into the urine)
Hyperkalaemia (damage to or disease of the kidney)
Hypokalaemia (low potassium)

60+:

Asthenia (weakness)
Confusional state
Pneumonia
Anxiety
Arthralgia (joint pain)
Blood creatinine increased
Blood urea increased
Bone disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cellulitis (infection under the skin)

What are the existing conditions these people have? *

Irritable Bowel Syndrome: 22 people, 30.99%
Breast Cancer Metastatic: 22 people, 30.99%
Hiv Infection: 5 people, 7.04%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 7.04%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 5.63%
High Blood Pressure: 4 people, 5.63%
High Blood Cholesterol: 4 people, 5.63%

* Approximation only. Some reports may have incomplete information.

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