Pregabalin and Emla drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pregabalin (pregabalin) and Emla (lidocaine; prilocaine). Common drug interactions include weight increased among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Pregabalin and Emla. It is created by eHealthMe based on reports of 87 people who take the same drugs from the FDA, and is updated regularly.

What is Pregabalin?

Pregabalin has active ingredients of pregabalin. It is often used in fibromyalgia. eHealthMe is studying from 74,071 Pregabalin users. Check the latest studies of Pregabalin.

What is Emla?

Emla has active ingredients of lidocaine; prilocaine. eHealthMe is studying from 5,276 Emla users. Check the latest studies of Emla.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

87 people who take Pregabalin and Emla together, and have interactions are studied.

What are the common drug interactions of Pregabalin and Emla, by gender? *:

female:

Weight increased
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Thrombocytopenic purpura (a bleeding disorder in which the immune system destroys platelets)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Suicidal ideation
Hallucination, visual (seeing things that aren't there)
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Drug ineffective
Fatigue (feeling of tiredness)
Pyrexia (fever)

male:

Fatigue (feeling of tiredness)
Headache (pain in head)
Influenza like illness
Infusion related reaction
Leukaemia (blood or bone marrow cancer)
Malaise (a feeling of general discomfort or uneasiness)
Myalgia (muscle pain)
Oedema peripheral (superficial swelling)
Pneumonia
Pyrexia (fever)

What are the common drug interactions of Pregabalin and Emla, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Weight increased
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Thrombocytopenic purpura (a bleeding disorder in which the immune system destroys platelets)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Suicidal ideation

20-29:

n/a

30-39:

Chills (felling of cold)
Fatigue (feeling of tiredness)
Arterial injury
Arthralgia (joint pain)
Breast mass
Bronchial wall thickening
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Infection
Influenza
Lymphadenopathy (disease or enlargement of lymph nodes)

40-49:

Pericardial effusion (fluid around the heart)

50-59:

Abdominal pain
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Cough
Dyspnoea (difficult or laboured respiration)
Hypersensitivity
Leukopenia (less number of white blood cells in blood)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscular weakness (muscle weakness)

60+:

Hallucination, visual (seeing things that aren't there)
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Arrhythmia (irregular heartbeat)
Clostridium test positive
Dermatosis (a disease of the skin, esp. one that does not cause inflammation)
Diarrhoea
Drug abuse
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Full blood count decreased

What are the existing conditions these people have? *

Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 48 people, 55.17%
Pain: 14 people, 16.09%
Constipation: 7 people, 8.05%
Stress And Anxiety: 6 people, 6.90%
Depression: 6 people, 6.90%
Headache (pain in head): 5 people, 5.75%

* Approximation only. Some reports may have incomplete information.

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