Epinephrine and Epidiolex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epinephrine (epinephrine) and Epidiolex (cannabidiol). Common drug interactions include drug hypersensitivity among females and seizure among males.

The phase IV clinical study analyzes what interactions people have when they take Epinephrine and Epidiolex. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Epinephrine?

Epinephrine has active ingredients of epinephrine. It is often used in asthma. eHealthMe is studying from 21,290 Epinephrine users. Check the latest studies of Epinephrine.

What is Epidiolex?

Epidiolex has active ingredients of cannabidiol. eHealthMe is studying from 18,763 Epidiolex users. Check the latest studies of Epidiolex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

68 people who take Epinephrine and Epidiolex together, and have interactions are studied.

Epinephrine and Epidiolex drug interactions.

What are the common drug interactions of Epinephrine and Epidiolex, by gender? *:

female:

Drug hypersensitivity
Metapneumovirus infection (infection with human metapneumovirus)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Ear infection
Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (subset of children and adolescents who have obsessive compulsive disorder (ocd) and/or tic disorders, and in whom symptoms worsen following strep. infections such as ""strep throat"" and scarlet fever)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Pneumonia
Sinusitis (inflammation of sinus)
Nasopharyngitis (inflammation of the nasopharynx)
Dyskinesia (abnormality or impairment of voluntary movement)

male:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Acute respiratory failure
Irritability
Psychomotor hyperactivity (feelings of extreme restlessness)
Respiration (transport of oxygen from the outside air to the cells within tissues)
Weight decreased
Ear infection
Infusion site pain
Agitation (state of anxiety or nervous excitement)
Biliary tract disorder

What are the common drug interactions of Epinephrine and Epidiolex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Acute respiratory failure
Gastritis (inflammation of stomach)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Rash
Respiration (transport of oxygen from the outside air to the cells within tissues)
Nasopharyngitis (inflammation of the nasopharynx)
Pneumonia
Upper respiratory tract infection
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

10-19:

Hospitalisation
Hyperhidrosis (abnormally increased sweating)
Infusion related reaction
Irritability
Rash
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)
Skin irritation
Viral infection
Urinary tract infection

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 30 people, 44.12%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 7 people, 10.29%
Metabolic Disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues): 7 people, 10.29%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 7 people, 10.29%
Combined Immunodeficiency: 6 people, 8.82%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 5 people, 7.35%
Immunodeficiency: 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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