Premarin and Carpine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Premarin (estrogens, conjugated) and Carpine (pilocarpine hydrochloride). Common drug interactions include nausea among females.

The phase IV clinical study analyzes what interactions people have when they take Premarin and Carpine. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

What is Carpine?

Carpine has active ingredients of pilocarpine hydrochloride. eHealthMe is studying from 5,561 Carpine users. Check the latest studies of Carpine.

On Aug, 11, 2026

77 people who take Premarin and Carpine together, and have interactions are studied.

What are the common drug interactions of Premarin and Carpine, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Urinary tract infection
Diarrhoea
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Tremor (trembling or shaking movements in one or more parts of your body)
Blood pressure increased
Fatigue (feeling of tiredness)
Gastric bypass
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Headache (pain in head)

male:

n/a

What are the common drug interactions of Premarin and Carpine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Asthenia (weakness)
Fatigue (feeling of tiredness)
Listless (lack of interest, energy, or spirit)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Pain
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)

40-49:

Gastric bypass
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Abnormal behaviour
Aphagia (inability or refusal to swallow)
Balance disorder
Cystitis (inflammation of the wall of the bladder)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)

50-59:

Bone pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Malaise (a feeling of general discomfort or uneasiness)
Abscess (pus)
Alopecia (absence of hair from areas of the body)
Aphthous ulcer (mouth ulcer)
C-reactive protein increased
Dyspnoea (difficult or laboured respiration)
Fall
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)

60+:

Nausea (feeling of having an urge to vomit)
Vomiting
Rectocele (a bulging of the front wall of the rectum into the back wall of the vagina)
Retching (strong involuntary effort to vomit)
Abdominal discomfort
Gait disturbance
Abdominal pain
Back pain
Blood oestrogen decreased
Blood pressure increased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 22 people, 28.57%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 20 people, 25.97%
Dry Mouth: 9 people, 11.69%
Pain: 9 people, 11.69%
Neuropathy Peripheral (surface nerve damage): 8 people, 10.39%
Neuralgia (pain in one or more nerves): 7 people, 9.09%
High Blood Cholesterol: 7 people, 9.09%
Depression: 6 people, 7.79%
Itching: 6 people, 7.79%
Dizziness: 6 people, 7.79%

* Approximation only. Some reports may have incomplete information.

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