Premarin and Genvoya drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Premarin (estrogens, conjugated) and Genvoya (cobicistat; elvitegravir; emtricitabine; tenofovir alafenamide fumarate). Common drug interactions include osteoporosis among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Premarin and Genvoya. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

What is Genvoya?

Genvoya has active ingredients of cobicistat; elvitegravir; emtricitabine; tenofovir alafenamide fumarate. It is often used in hiv infection. eHealthMe is studying from 13,538 Genvoya users. Check the latest studies of Genvoya.

On Jul, 19, 2026

20 people who take Premarin and Genvoya together, and have interactions are studied.

What are the common drug interactions of Premarin and Genvoya, by gender? *:

female:

Osteoporosis (bones weak and more likely to break)
Chronic kidney disease
Foot fracture
Bone density decreased
Osteopenia (a condition where bone mineral density is lower than normal)
Multiple fractures
Ankle fracture
Hypertension (high blood pressure)
Pain in extremity
Asthenia (weakness)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Emotional distress
Foot fracture
Pain

What are the common drug interactions of Premarin and Genvoya, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Ankle fracture
Foot fracture
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Back injury
Bone density decreased
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)

50-59:

Chronic kidney disease
Foot fracture
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Asthenia (weakness)
Bone density decreased
Multiple fractures
Osteopenia (a condition where bone mineral density is lower than normal)

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthralgia (joint pain)
Pain
Pain in extremity
Cd4 lymphocytes decreased
Back pain
Bone density decreased
Chronic kidney disease
Emotional distress
Foot fracture

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 15.00%
High Blood Pressure: 3 people, 15.00%
Vaginal Infection: 2 people, 10.00%
Skin Papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections): 2 people, 10.00%
Asthma: 2 people, 10.00%
Calcium Deficiency (lack of calcium): 2 people, 10.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 10.00%
Constipation: 2 people, 10.00%
Cough: 2 people, 10.00%
Depression: 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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