Prempro and Centrum silver drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prempro (estrogens, conjugated; medroxyprogesterone acetate) and Centrum silver (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e). Common drug interactions include pain among females.

The phase IV clinical study analyzes what interactions people have when they take Prempro and Centrum silver. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Prempro?

Prempro has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. It is often used in menopause. eHealthMe is studying from 42,950 Prempro users. Check the latest studies of Prempro.

What is Centrum silver?

Centrum silver has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 19,997 Centrum silver users. Check the latest studies of Centrum silver.

On Jul, 29, 2026

63 people who take Prempro and Centrum silver together, and have interactions are studied.

Prempro and Centrum silver drug interactions.

What are the common drug interactions of Prempro and Centrum Silver, by gender? *:

female:

Pain
Hypertension (high blood pressure)
Urinary tract infection
Weight decreased
Fall
Arthralgia (joint pain)
Blood glucose increased
Decreased appetite
Deformity (disfigurement)
Diarrhoea

male:

n/a

What are the common drug interactions of Prempro and Centrum Silver, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Arthralgia (joint pain)
Blindness transient (sudden loss of vision)
Blindness unilateral
Blood cholesterol increased
Blood triglycerides increased
Bone pain
Breast cancer female
Chills (felling of cold)
Drug effect decreased
Ear infection

50-59:

Heart rate irregular
Lower limb fracture
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Osteomyelitis (infection of bone)
Tricuspid valve stenosis (narrowing of tricuspid valve of heart)
Chronic kidney disease
Hysterectomy
Neoplasm malignant (cancer tumour)
Postoperative wound complication
Abasia (inability to walk)

60+:

Pain
Abdominal distension
Uterine cancer
Acne (skin problems that cause pimples)
Arthralgia (joint pain)
Back pain
Breast swelling
Drug ineffective
Vaginal haemorrhage (vaginal bleeding)
Alopecia (absence of hair from areas of the body)

What are the existing conditions these people have? *

Pain: 11 people, 17.46%
High Blood Cholesterol: 11 people, 17.46%
Osteopenia (a condition where bone mineral density is lower than normal): 9 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 14.29%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 9 people, 14.29%
Hypersensitivity: 8 people, 12.70%
High Blood Pressure: 8 people, 12.70%
Osteoporosis (bones weak and more likely to break): 7 people, 11.11%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 7 people, 11.11%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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