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Prezcobix and Gemfibrozil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prezcobix (cobicistat; darunavir ethanolate) and Gemfibrozil (gemfibrozil). Common drug interactions include anhedonia among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Prezcobix and Gemfibrozil. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Prezcobix?

Prezcobix has active ingredients of cobicistat; darunavir ethanolate. eHealthMe is studying from 2,113 Prezcobix users. Check the latest studies of Prezcobix.

What is Gemfibrozil?

Gemfibrozil has active ingredients of gemfibrozil. It is often used in high blood cholesterol. eHealthMe is studying from 18,213 Gemfibrozil users. Check the latest studies of Gemfibrozil.

On Jul, 06, 2026

12 people who take Prezcobix and Gemfibrozil together, and have interactions are studied.

Prezcobix and Gemfibrozil drug interactions.

What are the common drug interactions of Prezcobix and Gemfibrozil, by gender? *:

female:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Emotional distress
  4. Pain
  5. Bone density decreased
  6. Quality of life decreased
  7. Chronic kidney disease
  8. Decreased activity
  9. Depression
  10. Fatigue (feeling of tiredness)

male:

  1. Renal failure (kidney dysfunction)
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Impaired work ability
  4. Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  5. Nephrolithiasis (calculi in the kidneys)
  6. Renal impairment (severely reduced kidney function)
  7. Renal transplant
  8. Tooth loss
  9. Nephrogenic anaemia (anaemia due to kidney disease)
  10. Bone density decreased

What are the common drug interactions of Prezcobix and Gemfibrozil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Bone density decreased
  4. Decreased activity
  5. Emotional distress
  6. Pain
  7. Quality of life decreased
  8. Renal disorder (kidney disease)
  9. Renal failure (kidney dysfunction)

20-29:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Blood creatinine increased
  4. Bone density decreased
  5. Decreased activity
  6. Dysstasia (difficulty in standing)
  7. Emotional distress
  8. Fatigue (feeling of tiredness)
  9. Gait disturbance
  10. Pain

30-39:

n/a

40-49:

  1. Renal failure (kidney dysfunction)
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Anxiety
  4. Emotional distress
  5. Pain
  6. Azotaemia (excess of urea or other nitrogenous compounds in the blood)
  7. Decreased activity
  8. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  9. Hyperkalaemia (damage to or disease of the kidney)
  10. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

50-59:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Bone density decreased
  4. Emotional distress
  5. Multiple fractures
  6. Pain
  7. Renal failure (kidney dysfunction)
  8. Osteopenia (a condition where bone mineral density is lower than normal)

60+:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Pain
  4. Pain in extremity
  5. Pain in jaw
  6. Quality of life decreased
  7. Rib fracture
  8. Spinal fracture (fracture in one of vertebrae)
  9. Arthralgia (joint pain)
  10. Back pain

What are the existing conditions these people have? *

  1. Hiv Infection: 12 people, 100.00%
  2. High Blood Pressure: 7 people, 58.33%
  3. Diabetes: 5 people, 41.67%
  4. Infection: 4 people, 33.33%
  5. Procedural Pain: 4 people, 33.33%
  6. Nausea (feeling of having an urge to vomit): 3 people, 25.00%
  7. Stress And Anxiety: 3 people, 25.00%
  8. Asthma: 3 people, 25.00%
  9. Bacterial Infection: 3 people, 25.00%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 25.00%

* Approximation only. Some reports may have incomplete information.

Do you take Prezcobix and Gemfibrozil?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Prezcobix and Gemfibrozil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Prezcobix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Gemfibrozil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Prezcobix and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Gemfibrozil and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on cobicistat; darunavir ethanolate and gemfibrozil (the active ingredients of Prezcobix and Gemfibrozil, respectively), and Prezcobix and Gemfibrozil (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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