Prilosec and Fosamax plus d drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prilosec (omeprazole) and Fosamax plus d (alendronate sodium; cholecalciferol). Common drug interactions include depression among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Prilosec and Fosamax plus d. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Prilosec?

Prilosec has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 175,286 Prilosec users. Check the latest studies of Prilosec.

What is Fosamax plus d?

Fosamax plus d has active ingredients of alendronate sodium; cholecalciferol. It is often used in osteoporosis. eHealthMe is studying from 1,845 Fosamax plus d users. Check the latest studies of Fosamax plus d.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

44 people who take Prilosec and Fosamax plus d together, and have interactions are studied.

Prilosec and Fosamax plus d drug interactions.

What are the common drug interactions of Prilosec and Fosamax Plus D, by gender? *:

female:

Depression
Diastolic dysfunction
Drug intolerance (drug sensitivity)
Gastritis (inflammation of stomach)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Medical device complication
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Neuropathy peripheral (surface nerve damage)
Tooth disorder (tooth disease)
Blood cholesterol increased

male:

Chronic kidney disease
Migraine (headache)
Arachnoiditis (neuropathic disease caused by inflammation of the arachnoid)
Back disorder
Bunion (a painful swelling on the first joint of the big toe)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cellulitis (infection under the skin)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Constipation
Depression

What are the common drug interactions of Prilosec and Fosamax Plus D, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Arthralgia (joint pain)
Fall
Gait disturbance
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Femur fracture
Foaming at mouth (excess saliva secretion)
Incoherent (talking in a confused and unclear way)
Loss of consciousness
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)

50-59:

Rhinitis allergic (inflammation of the nasal airways due to allergy)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Sinus headache (headache caused by sinus infections)
Skin ulcer
Spinal osteoarthritis (joint cartilage loss in spine)
Tooth disorder (tooth disease)
Vertebral foraminal stenosis (narrowing of the intervertebral foramen)
Abscess jaw (tooth abscess or root abscess)
Blood triglycerides increased

60+:

Fall
Adverse drug reaction
Diastolic dysfunction
Dizziness
Drug intolerance (drug sensitivity)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Femur fracture
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Forearm fracture (fracture in between wrist to elbow)

What are the existing conditions these people have? *

Osteopenia (a condition where bone mineral density is lower than normal): 19 people, 43.18%
High Blood Pressure: 4 people, 9.09%
Multiple Myeloma (cancer of the plasma cells): 3 people, 6.82%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 6.82%
High Blood Cholesterol: 3 people, 6.82%
Depression: 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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