Primaxin and Cefuroxime drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Primaxin (cilastatin sodium; imipenem) and Cefuroxime (cefuroxime sodium). Common drug interactions include gastroenteritis among females and angioedema among males.

The phase IV clinical study analyzes what interactions people have when they take Primaxin and Cefuroxime. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Primaxin?

Primaxin has active ingredients of cilastatin sodium; imipenem. eHealthMe is studying from 4,540 Primaxin users. Check the latest studies of Primaxin.

What is Cefuroxime?

Cefuroxime has active ingredients of cefuroxime sodium. It is often used in sinusitis. eHealthMe is studying from 12,999 Cefuroxime users. Check the latest studies of Cefuroxime.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

20 people who take Primaxin and Cefuroxime together, and have interactions are studied.

Primaxin and Cefuroxime drug interactions.

What are the common drug interactions of Primaxin and Cefuroxime, by gender? *:

female:

Gastroenteritis (inflammation of stomach and intestine)
Pyelonephritis (inflammation of kidney caused by bacteria)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Blood creatinine increased
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Blood urea increased
Brain hypoxia (reduced supply of oxygen to the brain)
Cardiac arrest
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)

male:

Angioedema (rapid swelling of the dermis)
Blood creatinine increased
Complications of transplanted kidney
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hydronephrosis (water inside the kidney)
Somnolence (a state of near-sleep, a strong desire for sleep)
Hypotension (abnormally low blood pressure)
Post procedural haemorrhage (post procedural bleeding)
Staphylococcal infection (an infection with staphylococcus bacteria)
Dehydration (dryness resulting from the removal of water)

What are the common drug interactions of Primaxin and Cefuroxime, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Complications of transplanted kidney
Hydronephrosis (water inside the kidney)
Blood creatinine increased
C-reactive protein increased
Infectious mononucleosis (infection usually caused by the epstein-barr virus)
Lymphadenopathy (disease or enlargement of lymph nodes)
Nephritis interstitial (a kidney condition characterized by swelling in between the kidney tubules)
Pyrexia (fever)
Renal failure acute (rapid kidney dysfunction)

30-39:

n/a

40-49:

Angioedema (rapid swelling of the dermis)
Blood creatinine increased
Dehydration (dryness resulting from the removal of water)
Lymphocele (a collection of lymphatic fluid within the body not bordered by epithelial lining)
Urinary retention (the inability to completely or partially empty the bladder)
Cardiac arrest
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Somnolence (a state of near-sleep, a strong desire for sleep)

50-59:

Blood urea increased
Brain hypoxia (reduced supply of oxygen to the brain)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Haematoma infection (infection with collection of blood outside the blood vessels)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Hypoxia (low oxygen in tissues)
Anaemia (lack of blood)
Arterial haemorrhage
Blood creatinine increased

60+:

Gastroenteritis (inflammation of stomach and intestine)
Pyelonephritis (inflammation of kidney caused by bacteria)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Drug hypersensitivity

What are the existing conditions these people have? *

Gastrointestinal Infection (infection of stomach and intestine): 2 people, 10.00%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 2 people, 10.00%
Urinary Tract Infection: 1 person, 5.00%
Lung Infection: 1 person, 5.00%
Gastroenteritis (inflammation of stomach and intestine): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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