Primidone and Creon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Primidone (primidone) and Creon (pancrelipase (amylase;lipase;protease)). Common drug interactions include glaucoma among females and abnormal faeces among males.

The phase IV clinical study analyzes what interactions people have when they take Primidone and Creon. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Primidone?

Primidone has active ingredients of primidone. It is often used in essential tremor. eHealthMe is studying from 10,474 Primidone users. Check the latest studies of Primidone.

What is Creon?

Creon has active ingredients of pancrelipase (amylase;lipase;protease). It is often used in pancreatitis. eHealthMe is studying from 29,489 Creon users. Check the latest studies of Creon.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

42 people who take Primidone and Creon together, and have interactions are studied.

What are the common drug interactions of Primidone and Creon, by gender? *:

female:

Glaucoma (increased fluid pressure in the eye with vision loss)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hypertensive heart disease
Influenza like illness
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Infusion site haemorrhage (bleeding from infusion site)
Injection site mass
Injection site pain
Sinusitis (inflammation of sinus)
Blood creatinine increased

male:

Abnormal faeces (abnormal stool)
Bradycardia (abnormally slow heart action)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Coronary arterial stent insertion
Dizziness
Dyskinesia oesophageal (abnormality or impairment of voluntary movement of oesophageal)
Fatigue (feeling of tiredness)
Heart rate decreased
Intestinal obstruction
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

What are the common drug interactions of Primidone and Creon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Sinusitis (inflammation of sinus)
Upper respiratory tract infection

50-59:

n/a

60+:

Blood creatinine increased
Renal impairment (severely reduced kidney function)
Eating disorder
Fall
Feeling cold
Fistula (an abnormal connection or passageway between two)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Hypotension (abnormally low blood pressure)
Infection
Iritis (painful inflammation of the iris of the eye)

What are the existing conditions these people have? *

High Blood Cholesterol: 14 people, 33.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 26.19%
Pain: 9 people, 21.43%
Sleep Disorder: 8 people, 19.05%
Indigestion: 8 people, 19.05%
Immunodeficiency Common Variable: 7 people, 16.67%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 7 people, 16.67%
Raynaud's Phenomenon (discoloration of the fingers, toes, and occasionally other areas): 7 people, 16.67%
Pulmonary Embolism (blockage of the main artery of the lung): 7 people, 16.67%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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