Prinivil and Skelaxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prinivil (lisinopril) and Skelaxin (metaxalone). Common drug interactions include multi-organ failure among females and myocardial infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Prinivil and Skelaxin. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Prinivil?

Prinivil has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 20,152 Prinivil users. Check the latest studies of Prinivil.

What is Skelaxin?

Skelaxin has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 9,706 Skelaxin users. Check the latest studies of Skelaxin.

On Jul, 05, 2026

49 people who take Prinivil and Skelaxin together, and have interactions are studied.

Prinivil and Skelaxin drug interactions.

What are the common drug interactions of Prinivil and Skelaxin, by gender? *:

female:

Multi-organ failure (multisystem organ failure)
Presyncope
Sinusitis (inflammation of sinus)
Tuberculin test positive
Upper respiratory tract infection
Uterine cancer
Cardiomyopathy (weakening of the heart muscle)
Vomiting
Blood cholesterol increased
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)

male:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Joint sprain (an injury to joint surrounding flexible fibres)
Ligament sprain (ligament stretched)
Memory impairment
Overdose
Pain in extremity
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Rash
Spinal cord disorder (disease of spinal cord)

What are the common drug interactions of Prinivil and Skelaxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Insomnia (sleeplessness)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Cholecystitis (infection of gallbladder)
Influenza like illness
Urinary tract infection
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Intracardiac thrombus (presence of a circumscribed mass with heart wall)
Mass

30-39:

Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Headache (pain in head)
Meningitis cryptococcal (bacterial inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)

40-49:

Fibromyalgia (a long-term condition which causes pain all over the body)
Pain
Pulmonary sarcoidosis (growth of tiny collections of inflammatory cells in lungs)
Tongue neoplasm malignant stage unspecified
Abdominal pain
Aspartate aminotransferase increased
Cataract (clouding of the lens inside the eye)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Chronic kidney disease

50-59:

Acute myocardial infarction (acute heart attack)
Anaemia (lack of blood)
Angioedema (rapid swelling of the dermis)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Arthralgia (joint pain)
Bone disorder
Bone erosion
Bradycardia (abnormally slow heart action)

60+:

Arthralgia (joint pain)
Drug hypersensitivity
Asthenia (weakness)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Chronic kidney disease
Depression
Diastolic dysfunction
Gait disturbance
Heart rate decreased
Hyperhidrosis (abnormally increased sweating)

What are the existing conditions these people have? *

Pain: 12 people, 24.49%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 16.33%
High Blood Cholesterol: 6 people, 12.24%
Stress And Anxiety: 4 people, 8.16%
Asthma: 4 people, 8.16%
Renal Disorder (kidney disease): 3 people, 6.12%
Osteoporosis (bones weak and more likely to break): 3 people, 6.12%
Neuralgia (pain in one or more nerves): 3 people, 6.12%
Muscle Spasms (muscle contraction): 3 people, 6.12%
Fluid Retention (an abnormal accumulation of fluid in the blood): 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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