Proamatine and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Proamatine (midodrine hydrochloride) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include dyspnoea among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Proamatine and Flexeril. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Proamatine?

Proamatine has active ingredients of midodrine hydrochloride. It is often used in hypotension. eHealthMe is studying from 968 Proamatine users. Check the latest studies of Proamatine.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

20 people who take Proamatine and Flexeril together, and have interactions are studied.

Proamatine and Flexeril drug interactions.

What are the common drug interactions of Proamatine and Flexeril, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Drug hypersensitivity
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Urticaria (rash of round, red welts on the skin that itch intensely)
Headache (pain in head)
Dehydration (dryness resulting from the removal of water)

male:

Arthralgia (joint pain)
Cardiac disorder
Adrenal disorder
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Chronic kidney disease
Diarrhoea
Failure to thrive (inadequate weight gain and physical growth in children)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

What are the common drug interactions of Proamatine and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Adrenal disorder
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Diarrhoea
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Nausea (feeling of having an urge to vomit)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Vomiting

30-39:

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Drug hypersensitivity
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

40-49:

Drug hypersensitivity
Headache (pain in head)
Heart rate increased
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Palpitations (feelings or sensations that your heart is pounding or racing)
Vomiting

50-59:

Chills (felling of cold)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Dystonia (abnormal muscle tone)
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Nausea (feeling of having an urge to vomit)
Vision blurred
Chronic kidney disease

60+:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Lung adenocarcinoma (a form of non-small cell lung cancer)
Lung neoplasm malignant (cancer tumour of lung)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Osteopenia (a condition where bone mineral density is lower than normal)
Pain in extremity
Upper limb fracture
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Breast cancer female

What are the existing conditions these people have? *

Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 4 people, 20.00%
Pain: 4 people, 20.00%
Stress And Anxiety: 3 people, 15.00%
Constipation: 2 people, 10.00%
Headache (pain in head): 2 people, 10.00%
Behcet's Syndrome (involves inflammation of the blood vessels): 2 people, 10.00%
Neck Pain: 2 people, 10.00%
Dizziness: 1 person, 5.00%
Fever: 1 person, 5.00%
Dyspnea (difficult or laboured breathing): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Proamatine and Flexeril?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously