Proamatine and Optimark drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Proamatine (midodrine hydrochloride) and Optimark (gadoversetamide). Common drug interactions include nephrogenic systemic fibrosis among females and nephrogenic systemic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Proamatine and Optimark. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Proamatine?

Proamatine has active ingredients of midodrine hydrochloride. It is often used in hypotension. eHealthMe is studying from 968 Proamatine users. Check the latest studies of Proamatine.

What is Optimark?

Optimark has active ingredients of gadoversetamide. eHealthMe is studying from 3,055 Optimark users. Check the latest studies of Optimark.

On Jul, 20, 2026

12 people who take Proamatine and Optimark together, and have interactions are studied.

Proamatine and Optimark drug interactions.

What are the common drug interactions of Proamatine and Optimark, by gender? *:

female:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
Anxiety
Emotional distress
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Mobility decreased (ability to move is reduced)
Oedema peripheral (superficial swelling)
Asthenia (weakness)
Joint range of motion decreased (disease of joint movement)
Muscle tightness

male:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Deformity (disfigurement)
Device related infection
Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
General physical health deterioration (weak health status)
Hypoaesthesia (reduced sense of touch or sensation)
Joint range of motion decreased (disease of joint movement)
Mobility decreased (ability to move is reduced)
Muscle tightness

What are the common drug interactions of Proamatine and Optimark, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Deformity (disfigurement)
Erythema (redness of the skin)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
Rash
Rash papular (redness with papule)
Scar
Septic shock (shock due to blood infection)
Skin atrophy (wasting of skin)
Skin exfoliation (removal of the oldest dead skin cells)

40-49:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Anxiety
Emotional distress
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
General physical health deterioration (weak health status)
Injury
Lower extremity mass (mass in lower legs)
Mobility decreased (ability to move is reduced)
Oedema peripheral (superficial swelling)
Pain

50-59:

Anxiety
Asthenia (weakness)
Pain
Quality of life decreased
Skin tightness
Skin discolouration (change of skin colour)
Fatigue (feeling of tiredness)
Skin hyperpigmentation (disorders affect the colour of your skin)
Emotional distress
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)

60+:

n/a

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Abdominal: 9 people, 75.00%
Nuclear Magnetic Resonance Imaging Brain: 6 people, 50.00%
Renal Mass (mass in kidney): 2 people, 16.67%
Pressure Ulcer: 2 people, 16.67%
Osteomyelitis (infection of bone): 2 people, 16.67%
Neck Pain: 2 people, 16.67%
Liver Disorder (liver diseases): 2 people, 16.67%
Venous Occlusion (the blocking of venous return): 1 person, 8.33%
Kidney Transplant Rejection: 1 person, 8.33%
Infection: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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