Proamatine and Seroquel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Proamatine (midodrine hydrochloride) and Seroquel (quetiapine fumarate). Common drug interactions include cyst rupture among females and hallucination among males.

The phase IV clinical study analyzes what interactions people have when they take Proamatine and Seroquel. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Proamatine?

Proamatine has active ingredients of midodrine hydrochloride. It is often used in hypotension. eHealthMe is studying from 968 Proamatine users. Check the latest studies of Proamatine.

What is Seroquel?

Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. eHealthMe is studying from 120,285 Seroquel users. Check the latest studies of Seroquel.



On Jul, 14, 2026

37 people who take Proamatine and Seroquel together, and have interactions are studied.

Proamatine and Seroquel drug interactions.

What are the common drug interactions of Proamatine and Seroquel, by gender? *:

female:

  1. Cyst rupture (fluid leakage from sac)
  2. Dehydration (dryness resulting from the removal of water)
  3. Emotional distress
  4. Enterocutaneous fistula
  5. Fibromyalgia (a long-term condition which causes pain all over the body)
  6. Fistula (an abnormal connection or passageway between two)
  7. Gait disturbance
  8. Gastric disorder (disease of stomach)
  9. Hallucination, visual (seeing things that aren't there)
  10. Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)

male:

  1. Hallucination (an experience involving the perception of something not present)
  2. Dysphagia (a condition in which swallowing is difficult or painful)
  3. Screaming (a long loud piercing cry)
  4. Neoplasm malignant (cancer tumour)
  5. Confusional state
  6. Hospitalisation
  7. Delusion (a false belief or opinion)
  8. Plasma cell myeloma (cancer that begins in plasma cells)
  9. Drug ineffective
  10. Cardiac disorder

What are the common drug interactions of Proamatine and Seroquel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Blood glucose decreased
  2. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  3. Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
  4. Gestational diabetes (diabetes in pregnancy)
  5. Hypoglycaemia (deficiency of glucose in the bloodstream)
  6. Ketoacidosis (high concentrations of ketone bodies in blood)

40-49:

  1. Abdominal pain
  2. Acute respiratory failure
  3. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  4. Hyperglycaemia (high blood sugar)
  5. Respiratory distress (difficulty in breathing)
  6. Type 2 diabetes mellitus

50-59:

  1. Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
  2. Hypoaesthesia (reduced sense of touch or sensation)
  3. Immunodeficiency
  4. Irritability
  5. Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
  6. Poor quality sleep
  7. Purulent discharge (discharge that contains pus)
  8. Sepsis (a severe blood infection that can lead to organ failure and death)
  9. Small intestinal obstruction (blockage in small intestine)
  10. Vision blurred

60+:

  1. Hallucination (an experience involving the perception of something not present)
  2. Pneumonia
  3. Fall
  4. Neoplasm malignant (cancer tumour)
  5. Confusional state
  6. Hospitalisation
  7. Delusion (a false belief or opinion)
  8. Plasma cell myeloma (cancer that begins in plasma cells)
  9. Drug ineffective
  10. Cardiac disorder

What are the existing conditions these people have? *

  1. Pain: 15 people, 40.54%
  2. Hallucinations (sensations that appear real but are created by your mind): 11 people, 29.73%
  3. Parkinson's Disease: 7 people, 18.92%
  4. Depression: 6 people, 16.22%
  5. Stress And Anxiety: 5 people, 13.51%
  6. Delusion (a false belief or opinion): 5 people, 13.51%
  7. Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 4 people, 10.81%
  8. Constipation: 4 people, 10.81%
  9. Wheezing (a high-pitched whistling sound made while you breath): 2 people, 5.41%
  10. Cardiac Disorder: 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Proamatine and Seroquel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Proamatine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Seroquel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Proamatine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Seroquel and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on midodrine hydrochloride and quetiapine fumarate (the active ingredients of Proamatine and Seroquel, respectively), and Proamatine and Seroquel (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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