Probenecid and Gabapentin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Probenecid (probenecid) and Gabapentin (gabapentin). Common drug interactions include haematemesis among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Probenecid and Gabapentin. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Probenecid?

Probenecid has active ingredients of probenecid. It is often used in gout. eHealthMe is studying from 560 Probenecid users. Check the latest studies of Probenecid.

What is Gabapentin?

Gabapentin has active ingredients of gabapentin. It is often used in peripheral neuropathy. eHealthMe is studying from 322,987 Gabapentin users. Check the latest studies of Gabapentin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

27 people who take Probenecid and Gabapentin together, and have interactions are studied.

Probenecid and Gabapentin drug interactions.

What are the common drug interactions of Probenecid and Gabapentin, by gender? *:

female:

Haematemesis (vomiting of blood)
Haematochezia (passage of stools containing blood)
Hospitalisation
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Idiopathic pulmonary fibrosis (chronic lung disease)
Lung infection
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Death

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Cardiomegaly (increased size of heart than normal)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Death
Device related infection
Gastritis (inflammation of stomach)
Hyperkalaemia (damage to or disease of the kidney)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Neoplasm (tumour)

What are the common drug interactions of Probenecid and Gabapentin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Unresponsive to stimuli
Adenovirus test positive
Cardiac arrest
Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hypertension (high blood pressure)
Multi-organ disorder (multiple organ disease)
Polyomavirus test positive

10-19:

Haematemesis (vomiting of blood)
Haematochezia (passage of stools containing blood)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

60+:

Death
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Device related infection
Disability
Gastritis (inflammation of stomach)
Hyperkalaemia (damage to or disease of the kidney)
Injury
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Neoplasm (tumour)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 6 people, 22.22%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 7.41%
Pain: 2 people, 7.41%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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