Probenecid and Nexium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Probenecid (probenecid) and Nexium (esomeprazole magnesium). Common drug interactions include death among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Probenecid and Nexium. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Probenecid?

Probenecid has active ingredients of probenecid. It is often used in gout. eHealthMe is studying from 560 Probenecid users. Check the latest studies of Probenecid.

What is Nexium?

Nexium has active ingredients of esomeprazole magnesium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 245,678 Nexium users. Check the latest studies of Nexium.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

27 people who take Probenecid and Nexium together, and have interactions are studied.

Probenecid and Nexium drug interactions.

What are the common drug interactions of Probenecid and Nexium, by gender? *:

female:

Death
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Altered state of consciousness (altered state of mind)
Bladder dilatation
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest pain
Constipation
Drug hypersensitivity
Headache (pain in head)
Heart valve incompetence (heart's valves do not work correctly)

male:

Pneumonia
Cardiac failure congestive
Blood glucose increased
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dehydration (dryness resulting from the removal of water)
Dizziness
Gait disturbance
Hypertension (high blood pressure)
Limb injury
Mycosis fungoides (lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin)

What are the common drug interactions of Probenecid and Nexium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Pneumonia
Anxiety
Chronic kidney disease
Depression
Injury
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

60+:

Pneumonia
Cardiac failure congestive
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dehydration (dryness resulting from the removal of water)
Dizziness
Fall
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypertension (high blood pressure)
Loss of consciousness
Mycosis fungoides (lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin)

What are the existing conditions these people have? *

High Blood Pressure: 10 people, 37.04%
Depression: 6 people, 22.22%
High Blood Cholesterol: 5 people, 18.52%
Pain: 4 people, 14.81%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 11.11%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 11.11%
Mycosis Fungoides (lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin): 3 people, 11.11%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 11.11%
Stress And Anxiety: 3 people, 11.11%
Cardiac Disorder: 3 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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