Probenecid and Spironolactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Probenecid (probenecid) and Spironolactone (spironolactone). Common drug interactions include seizure among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Probenecid and Spironolactone. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Probenecid?

Probenecid has active ingredients of probenecid. It is often used in gout. eHealthMe is studying from 560 Probenecid users. Check the latest studies of Probenecid.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

31 people who take Probenecid and Spironolactone together, and have interactions are studied.

Probenecid and Spironolactone drug interactions.

What are the common drug interactions of Probenecid and Spironolactone, by gender? *:

female:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Dyspnoea (difficult or laboured respiration)
Anaemia (lack of blood)
Cardiac arrest
Catheter site infection (infection at the site of insertion)
Chills (felling of cold)
Death
Decreased appetite
Diarrhoea
Dizziness

male:

Abdominal discomfort
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Injury
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Pain
Parkinson's disease
Renal failure acute (rapid kidney dysfunction)
Restless legs syndrome (a powerful urge to move your legs)
Weight decreased
Activities of daily living impaired

What are the common drug interactions of Probenecid and Spironolactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Depressed level of consciousness
Cardiac arrest
Neutropenia (an abnormally low number of neutrophils)
Pyrexia (fever)
Swelling face
Wheezing (a high-pitched whistling sound made while you breath)

10-19:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Chills (felling of cold)
Decreased appetite
Dizziness
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

60+:

Abdominal discomfort
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Injury
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Pain
Parkinson's disease
Renal failure acute (rapid kidney dysfunction)
Restless legs syndrome (a powerful urge to move your legs)
Weight decreased
Activities of daily living impaired

What are the existing conditions these people have? *

Nausea And Vomiting: 9 people, 29.03%
Haemorrhage (bleeding): 9 people, 29.03%
Nephropathy Toxic (damage to kidney due to toxins): 9 people, 29.03%
Ureteritis (inflammation of the ureter): 8 people, 25.81%
Stress And Anxiety: 8 people, 25.81%
Pain: 8 people, 25.81%
Nausea (feeling of having an urge to vomit): 8 people, 25.81%
Adenovirus Infection: 7 people, 22.58%
High Blood Pressure: 5 people, 16.13%
Infection: 3 people, 9.68%

* Approximation only. Some reports may have incomplete information.

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