Prochlorperazine maleate and Topamax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prochlorperazine maleate (prochlorperazine maleate) and Topamax (topiramate). Common drug interactions include stress fracture among females and gait disturbance among males.

The phase IV clinical study analyzes what interactions people have when they take Prochlorperazine maleate and Topamax. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Prochlorperazine maleate?

Prochlorperazine maleate has active ingredients of prochlorperazine maleate. It is often used in nausea. eHealthMe is studying from 10,027 Prochlorperazine maleate users. Check the latest studies of Prochlorperazine maleate.

What is Topamax?

Topamax has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 58,955 Topamax users. Check the latest studies of Topamax.

On Aug, 04, 2026

69 people who take Prochlorperazine maleate and Topamax together, and have interactions are studied.

Prochlorperazine maleate and Topamax drug interactions.

What are the common drug interactions of Prochlorperazine Maleate and Topamax, by gender? *:

female:

Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Weight increased
Rash
Accident
Affective disorder (mental disorder)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
Back pain
Blood pressure increased

male:

Gait disturbance
Pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Spondyloarthropathy (any joint disease of the vertebral column)
Fall
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Synovitis (inflammation of the synovial membrane)
Chronic kidney disease
Depression
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the common drug interactions of Prochlorperazine Maleate and Topamax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Aphasia (damage to the parts of the brain that control language)
Headache (pain in head)
Muscular weakness (muscle weakness)
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Diplopia (double vision)
Hypoaesthesia (reduced sense of touch or sensation)
Arthralgia (joint pain)
Post lumbar puncture syndrome
Abdominal pain
Bone loss

40-49:

Arthralgia (joint pain)
Accident
Affective disorder (mental disorder)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
Asthenia (weakness)
Bone loss
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cellulitis (infection under the skin)

50-59:

Breast cancer stage ii
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Asthenia (weakness)
Back pain
Constipation
Death
Diarrhoea
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)

60+:

Pain
Drug ineffective
Chronic kidney disease
Compression fracture (fracture due to pressure caused by injury)
Disease progression
Dry mouth
Essential hypertension (primary hypertension)
Fibromyalgia (a long-term condition which causes pain all over the body)
Haemorrhage (bleeding)
Immunoglobulins decreased

What are the existing conditions these people have? *

Pain: 16 people, 23.19%
Ovarian Cancer (cancer of ovary): 9 people, 13.04%
Fibromyalgia (a long-term condition which causes pain all over the body): 9 people, 13.04%
Wheezing (a high-pitched whistling sound made while you breath): 8 people, 11.59%
Insomnia (sleeplessness): 8 people, 11.59%
Spondyloarthropathy (any joint disease of the vertebral column): 8 people, 11.59%
Dyspnea (difficult or laboured breathing): 8 people, 11.59%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 11.59%
Muscle Spasms (muscle contraction): 8 people, 11.59%
Diarrhea: 7 people, 10.14%

* Approximation only. Some reports may have incomplete information.

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