Profen and Aleve pm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Aleve pm (diphenhydramine hydrochloride; naproxen sodium). Common drug interactions include drug ineffective among females and cellulitis among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Aleve pm. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,310 Profen users. Check the latest studies of Profen.

What is Aleve pm?

Aleve pm has active ingredients of diphenhydramine hydrochloride; naproxen sodium. eHealthMe is studying from 2,094 Aleve pm users. Check the latest studies of Aleve pm.

On Apr, 22, 2026

20 people who take Profen and Aleve pm together, and have interactions are studied.

What are the common drug interactions of Profen and Aleve Pm, by gender? *:

female:

Drug ineffective
Abdominal discomfort
Diarrhoea
Headache (pain in head)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peripheral swelling
Restlessness (not able to rest)
Wound infection staphylococcal
Abdominal abscess (collection of pus in abdomen)
Abdominal pain upper

male:

Cellulitis (infection under the skin)
Device related infection
Therapeutic response unexpected
Thyroid disorder (thyroid diseases)
Weight increased
Drug ineffective
Fall
Hot flush (sudden feelings of heat)
Hypertension (high blood pressure)
Joint injury

What are the common drug interactions of Profen and Aleve Pm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug ineffective

40-49:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peripheral swelling
Restlessness (not able to rest)
Wound infection staphylococcal
Hot flush (sudden feelings of heat)

50-59:

Headache (pain in head)
Death

60+:

Abdominal discomfort
Abdominal pain upper
Nausea (feeling of having an urge to vomit)
Pain in extremity
Somnolence (a state of near-sleep, a strong desire for sleep)
Therapeutic response unexpected
Thyroid disorder (thyroid diseases)
Weight increased
Cellulitis (infection under the skin)
Device related infection

What are the existing conditions these people have? *

Sleep Disorder: 3 people, 15.00%
Headache (pain in head): 2 people, 10.00%
Thyroid Diseases: 1 person, 5.00%
Infection: 1 person, 5.00%
Completed Suicide (act of taking one's own life): 1 person, 5.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 5.00%
Cystic Fibrosis (disease of the secretary glands): 1 person, 5.00%
Depression: 1 person, 5.00%
Essential Tremor: 1 person, 5.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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