Profen and Amerge drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Amerge (naratriptan hydrochloride). Common drug interactions include peripheral swelling among females and disturbance in attention among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Amerge. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Amerge?

Amerge has active ingredients of naratriptan hydrochloride. It is often used in migraine. eHealthMe is studying from 1,470 Amerge users. Check the latest studies of Amerge.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

92 people who take Profen and Amerge together, and have interactions are studied.

What are the common drug interactions of Profen and Amerge, by gender? *:

female:

Peripheral swelling
Rash
Renal failure (kidney dysfunction)
Restlessness (not able to rest)
Stress
Therapeutic response unexpected
Abdominal discomfort
Abdominal pain
Adrenal mass
Adrenomegaly (enlarged adrenal glands)

male:

Disturbance in attention
Drug toxicity
Crying
Drug hypersensitivity
Drug ineffective
Drug intolerance (drug sensitivity)
Foot fracture
Haemorrhage (bleeding)
Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)

What are the common drug interactions of Profen and Amerge, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anxiety
Emotional distress
General physical health deterioration (weak health status)
Injury
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Cholecystitis chronic (long lasting infection of gallbladder)
Gallbladder disorder
Nausea (feeling of having an urge to vomit)
Pulmonary embolism (blockage of the main artery of the lung)

20-29:

Iron deficiency anaemia
Pulmonary embolism (blockage of the main artery of the lung)
Asthma
Headache (pain in head)
Acute hepatic failure
Arrhythmia (irregular heartbeat)
Suicide attempt
Transplant rejection (a transplant material is not worked)
Atelectasis (partial or complete collapse of the lung)
Chondromalacia (anterior knee pain due to irritation of the cartilage on the under surface of the kneecap)

30-39:

Pulmonary embolism (blockage of the main artery of the lung)
Adrenal mass
Adrenomegaly (enlarged adrenal glands)
Alopecia (absence of hair from areas of the body)
Blood pressure increased
Chest discomfort
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Headache (pain in head)
Hepatic cyst

40-49:

Chest pain
Pulmonary embolism (blockage of the main artery of the lung)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Disturbance in attention
Drug toxicity
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Hypertension (high blood pressure)
Neck pain
Nephrolithiasis (calculi in the kidneys)
Pleuritic pain

50-59:

Pigmentation disorder (disturbances of human skin colour)
Pruritus (severe itching of the skin)
Psychomotor hyperactivity (feelings of extreme restlessness)
Rash
Respiratory tract congestion (blockage on respiratory system)
Seasonal affective disorder (a type of depression that occurs at a certain time of the year, usually in the winter)
Seasonal allergy (allergic condition due to certain season)
Temperature intolerance (inability to go in temperature)
Thirst
Tinnitus (a ringing in the ears)

60+:

Headache (pain in head)
Anxiety
Nervousness
Palpitations (feelings or sensations that your heart is pounding or racing)
Restlessness (not able to rest)
Stress
Abdominal discomfort
Abdominal adhesions (inflammation of abdomen)
Ascites (accumulation of fluid in the abdominal cavity)
C-reactive protein increased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 20 people, 21.74%
Headache (pain in head): 8 people, 8.70%
Acne (skin problems that cause pimples): 7 people, 7.61%
Premenstrual Syndrome: 6 people, 6.52%
Birth Control: 6 people, 6.52%
Stress And Anxiety: 5 people, 5.43%
Seasonal Affective Disorder (a type of depression that occurs at a certain time of the year, usually in the winter): 5 people, 5.43%
Nausea (feeling of having an urge to vomit): 5 people, 5.43%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 5.43%

* Approximation only. Some reports may have incomplete information.

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