Profen and Capsaicin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Capsaicin (capsicum). Common drug interactions include weight increased among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Capsaicin. It is created by eHealthMe based on reports of 80 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,312 Profen users. Check the latest studies of Profen.

What is Capsaicin?

Capsaicin has active ingredients of capsicum. eHealthMe is studying from 568 Capsaicin users. Check the latest studies of Capsaicin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

80 people who take Profen and Capsaicin together, and have interactions are studied.

What are the common drug interactions of Profen and Capsaicin, by gender? *:

female:

Weight increased
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Thrombocytopenic purpura (a bleeding disorder in which the immune system destroys platelets)
Malaise (a feeling of general discomfort or uneasiness)
Drug ineffective
Suicidal ideation
Erythema (redness of the skin)
Swelling face
Abdominal pain

male:

Drug ineffective
Bone density decreased
Mobility decreased (ability to move is reduced)
Multiple fractures
Osteonecrosis (death of bone)
Osteoporosis (bones weak and more likely to break)
Patella fracture
Anaemia of chronic disease
Ankle fracture
Blood cholesterol increased

What are the common drug interactions of Profen and Capsaicin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Weight increased
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Thrombocytopenic purpura (a bleeding disorder in which the immune system destroys platelets)
Suicidal ideation

20-29:

Dizziness
Dry mouth
Erythema (redness of the skin)
Malaise (a feeling of general discomfort or uneasiness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

30-39:

Drug ineffective
Impaired work ability
Peptic ulcer

40-49:

n/a

50-59:

Drug ineffective
Abdominal pain
Abdominal pain upper
Abnormal faeces (abnormal stool)
Blood cholesterol increased
Burning sensation
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Constipation
Diarrhoea
Erythema (redness of the skin)

60+:

Malaise (a feeling of general discomfort or uneasiness)
Confusional state
Bronchitis chemical (inflammation of the mucous membrane in the bronchial tubes due to chemical inhalation)
Chronic kidney disease
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Death
Depression
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Diverticular perforation (serious gastrointestinal condition in which the intestine's walls are perforated)
Dizziness

What are the existing conditions these people have? *

Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 54 people, 67.50%

* Approximation only. Some reports may have incomplete information.

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