Profen and Cenestin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Cenestin (estrogens, conjugated synthetic a). Common drug interactions include abdominal pain among females.

The phase IV clinical study analyzes what interactions people have when they take Profen and Cenestin. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Cenestin?

Cenestin has active ingredients of estrogens, conjugated synthetic a. It is often used in hormone replacement therapy. eHealthMe is studying from 1,301 Cenestin users. Check the latest studies of Cenestin.

On Jul, 26, 2026

23 people who take Profen and Cenestin together, and have interactions are studied.

What are the common drug interactions of Profen and Cenestin, by gender? *:

female:

Abdominal pain
Diarrhoea
Faeces discoloured
Muscular weakness (muscle weakness)
Accelerated hypertension (significant hypertension)
Arrhythmia (irregular heartbeat)
Cardiac murmur (an heart sound in valve abnormality)
Death
Faecal incontinence (a lack of control over passing stool)
Fall

male:

n/a

What are the common drug interactions of Profen and Cenestin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain upper
Arthralgia (joint pain)
Chest pain
Depressed level of consciousness
Dyspepsia (indigestion)
Fibromyalgia (a long-term condition which causes pain all over the body)
Heart rate increased
Hypertension (high blood pressure)
Palpitations (feelings or sensations that your heart is pounding or racing)

40-49:

Abdominal pain
Accelerated hypertension (significant hypertension)
Cardiac murmur (an heart sound in valve abnormality)
Death
Diarrhoea
Dizziness
Faecal incontinence (a lack of control over passing stool)
Fall
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)

50-59:

Abasia (inability to walk)
Depression
Diarrhoea
Dyspepsia (indigestion)
Faeces discoloured
Muscular weakness (muscle weakness)
Vomiting
Crying
Loss of control of legs
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

60+:

Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Rash
Respiratory failure (inadequate gas exchange by the respiratory system)
Septic shock (shock due to blood infection)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Dizziness
Injection site bruising
Injection site pain

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 30.43%
Gait Disturbance: 6 people, 26.09%
Muscle Spasms (muscle contraction): 6 people, 26.09%
Sleep Disorder: 3 people, 13.04%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 13.04%
Depression: 3 people, 13.04%
Hypersensitivity: 3 people, 13.04%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 13.04%
Infection: 2 people, 8.70%
Indigestion: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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