Profen and Glycine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Glycine (glycine). Common drug interactions include malignant pleural effusion among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Glycine. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Glycine?

Glycine has active ingredients of glycine. eHealthMe is studying from 1,064 Glycine users. Check the latest studies of Glycine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

63 people who take Profen and Glycine together, and have interactions are studied.

What are the common drug interactions of Profen and Glycine, by gender? *:

female:

Malignant pleural effusion (a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue lining of lung)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Myelosuppression (a decrease in the production of blood cells)
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Crying
Dyskinesia oesophageal (abnormality or impairment of voluntary movement of oesophageal)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Migraine (headache)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)

male:

Depression
Insomnia (sleeplessness)
Blood creatine phosphokinase increased
Blood creatinine increased
Blood pressure increased
Blood sodium decreased
Bone disorder
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Cardiomegaly (increased size of heart than normal)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the common drug interactions of Profen and Glycine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Cardiac arrest
Hyperkalaemia (damage to or disease of the kidney)
Oxygen saturation decreased
Pulmonary hypertension (increase in blood pressure in the lung artery)
Respiratory distress (difficulty in breathing)
Respiratory failure (inadequate gas exchange by the respiratory system)
Respiratory rate increased (excess breathing rate/min)
Respiratory tract infection
Tracheitis (an inflammation of the trachea)

10-19:

Contrast media allergy (reaction associated with the use of intravenous contrast material during radiology)
Drug hypersensitivity
Duodenal ulcer haemorrhage (bleeding duodenal ulcer)
Dyskinesia (abnormality or impairment of voluntary movement)

20-29:

Anaemia (lack of blood)
Anaplastic large cell lymphoma t- and null-cell types (t-cell or null-cell cancer, a type of blood cancer)
Malignant pleural effusion (a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue lining of lung)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Myelosuppression (a decrease in the production of blood cells)
Vomiting
Nausea (feeling of having an urge to vomit)
Pneumonia

30-39:

Confusional state
Depression
Disturbance in attention
Drug ineffective
Fear
Insomnia (sleeplessness)
Memory impairment
Sluggishness (lacking alertness)

40-49:

Abdominal distension
Coeliac artery compression syndrome (abdominal pain related to compression of the celiac artery)
Groin pain
Hepatic steatosis (fatty liver disease)
Hypertension (high blood pressure)
Liver injury
Platelet count increased
Tooth disorder (tooth disease)
Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

Serum ferritin decreased
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Somnolence (a state of near-sleep, a strong desire for sleep)
Suicidal ideation
Suicide attempt
Tibia fracture (fracture of lower leg bone)
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Alcohol detoxification
Alcoholism (problems with alcohol)
Aortic valve incompetence

60+:

Rash
Pneumonia
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Thrombocytopenia (decrease of platelets in blood)
Colorectal cancer metastatic (cancer of colon and rectal spreads to other parts)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Blood glucose decreased
Blood glucose increased

What are the existing conditions these people have? *

Pneumonia: 29 people, 46.03%
High Blood Pressure: 28 people, 44.44%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 27 people, 42.86%
Partial Seizures (seizures which affect only a part of the brain at onset): 27 people, 42.86%
Gout (uric acid crystals building up in the body): 22 people, 34.92%
High Blood Cholesterol: 21 people, 33.33%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 20 people, 31.75%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 20 people, 31.75%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 20 people, 31.75%
Clonic Convulsion (long lasting seizure): 15 people, 23.81%

* Approximation only. Some reports may have incomplete information.

Do you take Profen and Glycine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously