Profen and Increlex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Increlex (mecasermin recombinant). Common drug interactions include sepsis among females and breath odour among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Increlex. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Increlex?

Increlex has active ingredients of mecasermin recombinant. eHealthMe is studying from 1,010 Increlex users. Check the latest studies of Increlex.

On Jul, 09, 2026

23 people who take Profen and Increlex together, and have interactions are studied.

What are the common drug interactions of Profen and Increlex, by gender? *:

female:

Sepsis (a severe blood infection that can lead to organ failure and death)
Bacteraemia (presence of bacteria in the blood)
Anorexia nervosa (psychological disorder-eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Hereditary angioedema (recurrent episodes of severe swelling)
Urinary tract infection
Urticaria (rash of round, red welts on the skin that itch intensely)
Cerebral ventricle dilatation (enlargement of ventricle of brain)
Concussion (short loss of normal brain function in response to a head injury)
Drug ineffective
Exostosis (formation of new bone on the surface of a bone)

male:

Breath odour
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Vomiting
Blood pressure diastolic decreased
Cytomegalovirus chorioretinitis (infection of choroid and retina of the eye from virus)
Disease recurrence
Face oedema (swelling of face)
Gastritis (inflammation of stomach)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Headache (pain in head)

What are the common drug interactions of Profen and Increlex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Otitis media chronic (long lasting inflammation of the middle ear)
Tonsillar hypertrophy (enlargement of the tonsils)
Sinus congestion (blockage of sinus)
Nasal oedema (fluid collection in nose)
Swelling
Blood pressure diastolic decreased
Cerebral ventricle dilatation (enlargement of ventricle of brain)
Disease recurrence
Face oedema (swelling of face)
Heart rate increased

10-19:

Cytomegalovirus chorioretinitis (infection of choroid and retina of the eye from virus)
Gastritis (inflammation of stomach)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Headache (pain in head)
Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system)
Vomiting
Weight decreased

20-29:

n/a

30-39:

Anorexia nervosa (psychological disorder-eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Exostosis (formation of new bone on the surface of a bone)
Foot deformity (functional disability of foot)
Fracture
Urinary tract infection

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Hereditary Angioedema (recurrent episodes of severe swelling): 9 people, 39.13%
Immune System Disorder: 4 people, 17.39%
Growth Hormone Deficiency: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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