Profen and Isordil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Isordil (isosorbide dinitrate). Common drug interactions include dehydration among females and coronary artery occlusion among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Isordil. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Isordil?

Isordil has active ingredients of isosorbide dinitrate. eHealthMe is studying from 3,022 Isordil users. Check the latest studies of Isordil.

On Jul, 14, 2026

43 people who take Profen and Isordil together, and have interactions are studied.

What are the common drug interactions of Profen and Isordil, by gender? *:

female:

Dehydration (dryness resulting from the removal of water)
Emotional distress
Gait disturbance
Headache (pain in head)
Hypertension (high blood pressure)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Pulmonary embolism (blockage of the main artery of the lung)
Pyrexia (fever)

male:

Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Chronic kidney disease
Vomiting
Aortic valve incompetence
Blood potassium decreased
Bradycardia (abnormally slow heart action)
Diarrhoea
Dilatation ventricular
Lactic acidosis (low ph in body tissues)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Profen and Isordil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)

40-49:

Hypoaesthesia (reduced sense of touch or sensation)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Productive cough
Renal failure (kidney dysfunction)
Renal failure acute (rapid kidney dysfunction)
Vomiting

50-59:

Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Pulmonary embolism (blockage of the main artery of the lung)
Blood potassium decreased
Chest pain
Dilatation ventricular
Hypotension (abnormally low blood pressure)
Oxygen saturation decreased
Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Hypokalaemia (low potassium)

60+:

Injury
Renal failure (kidney dysfunction)
Foot deformity (functional disability of foot)
Gait disturbance
Gastrointestinal angiodysplasia haemorrhagic (a small vascular malformation of the gut with bleeding)
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Head injury
Hypotension (abnormally low blood pressure)
Lactic acidosis (low ph in body tissues)
Renal failure acute (rapid kidney dysfunction)

What are the existing conditions these people have? *

Cardiac Disorder: 5 people, 11.63%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 9.30%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 9.30%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 6.98%
High Blood Cholesterol: 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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