Profen and Kefzol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Kefzol (cefazolin sodium). Common drug interactions include nausea among females and actinomycosis among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Kefzol. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Kefzol?

Kefzol has active ingredients of cefazolin sodium. eHealthMe is studying from 628 Kefzol users. Check the latest studies of Kefzol.

On Aug, 09, 2026

35 people who take Profen and Kefzol together, and have interactions are studied.

What are the common drug interactions of Profen and Kefzol, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Oedema (fluid collection in tissue)
Pulmonary embolism (blockage of the main artery of the lung)
Agitation (state of anxiety or nervous excitement)
Aphthous stomatitis (mouth ulcer)
Arthralgia (joint pain)
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Asthenia (weakness)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Cardiac disorder

male:

Actinomycosis (infection that causes sores, or abscesses)
Adjustment disorder
Constipation
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Deep vein thrombosis postoperative (blood clot in a major vein that usually develops in the legs and/or pelvis after operation)
Deformity (disfigurement)
Depression
Diarrhoea
Dry eye (lack of adequate tears)

What are the common drug interactions of Profen and Kefzol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood cholesterol increased
Cholecystitis chronic (long lasting infection of gallbladder)
Cholecystitis infective (infection of gallbladder capable to infect other organs)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Device failure
Drug ineffective
Gallbladder disorder
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

30-39:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Gallbladder disorder
Atrioventricular block complete (heart block complete)
Cardiac failure
Heart rate decreased

40-49:

Pulmonary embolism (blockage of the main artery of the lung)

50-59:

Nervousness
Psychiatric symptom
Renal impairment (severely reduced kidney function)
Stress
Anxiety
Emotional distress
Fear
Injury
Multi-organ failure (multisystem organ failure)
Renal failure (kidney dysfunction)

60+:

Nausea (feeling of having an urge to vomit)
Oedema (fluid collection in tissue)
Chest pain
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Cyst (a closed sac)
Decreased interest
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Depressed mood

What are the existing conditions these people have? *

Birth Control: 6 people, 17.14%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 8.57%
Premenstrual Syndrome: 3 people, 8.57%
Traumatic Haemorrhage (a bleeding due to trauma): 2 people, 5.71%
Thrombosis (formation of a blood clot inside a blood vessel): 2 people, 5.71%
Sedation: 2 people, 5.71%
Inflammation: 2 people, 5.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.71%
Fungal Infection: 2 people, 5.71%
Bacterial Infection: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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