Profen and Lubiprostone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Lubiprostone (lubiprostone). Common drug interactions include chills among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Lubiprostone. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Lubiprostone?

Lubiprostone has active ingredients of lubiprostone. eHealthMe is studying from 957 Lubiprostone users. Check the latest studies of Lubiprostone.

On Aug, 08, 2026

39 people who take Profen and Lubiprostone together, and have interactions are studied.

Profen and Lubiprostone drug interactions.

What are the common drug interactions of Profen and Lubiprostone, by gender? *:

female:

Chills (felling of cold)
Confusional state
Conjunctival hyperaemia (congestion of conjunctival vessels)
Contusion (a type of hematoma of tissue in which capillaries)
Depression
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Diarrhoea
Disturbance in attention
Dyspnoea (difficult or laboured respiration)
Dystonia (abnormal muscle tone)

male:

Arthralgia (joint pain)
Constipation
Decreased appetite
Dizziness
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)
Exposure to chemical pollution
Fall
Feeling cold
Gait disturbance

What are the common drug interactions of Profen and Lubiprostone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Arthralgia (joint pain)
Constipation
Dyspnoea (difficult or laboured respiration)
Malaise (a feeling of general discomfort or uneasiness)
Oxygen saturation decreased
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Pyrexia (fever)
Respiratory distress (difficulty in breathing)
Upper respiratory tract infection

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Body temperature increased
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Hot flush (sudden feelings of heat)
Panic reaction

40-49:

Abdominal pain upper
Dizziness
Pancreatitis (inflammation of pancreas)
Urinary tract infection
Viral pharyngitis (inflammation of the throat or pharynx caused by viral infection)
Activated partial thromboplastin time prolonged
Anaemia (lack of blood)
Anxiety
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Hypertension (high blood pressure)

50-59:

Arthralgia (joint pain)
Pain in extremity
Death
Brachial plexus injury (brachial plexus injuries, are caused by damage to those nerves network that conducts signals from the spinal cord)
Conjunctival hyperaemia (congestion of conjunctival vessels)
Decreased appetite
Dysgeusia (disorder of the sense of taste)
Erythema (redness of the skin)
Exposure to chemical pollution
Fall

60+:

Fatigue (feeling of tiredness)
Chills (felling of cold)
Abnormal faeces (abnormal stool)
Adenocarcinoma pancreas (cancer of pancreas)
Anxiety
Arthralgia (joint pain)
Asthenia (weakness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood pressure decreased
Blood pressure increased

What are the existing conditions these people have? *

Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 8 people, 20.51%
Constipation: 7 people, 17.95%
High Blood Cholesterol: 5 people, 12.82%
Diabetes: 5 people, 12.82%
High Blood Pressure: 5 people, 12.82%
Impaired Gastric Emptying: 4 people, 10.26%
Asthma: 4 people, 10.26%
Autonomic Neuropathy (malfunction of the autonomic nervous system (ans)): 4 people, 10.26%
Fever: 4 people, 10.26%
Nausea (feeling of having an urge to vomit): 4 people, 10.26%

* Approximation only. Some reports may have incomplete information.

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