Profen and Oracea drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Oracea (doxycycline). Common drug interactions include chronic kidney disease among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Oracea. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Oracea?

Oracea has active ingredients of doxycycline. It is often used in rosacea. eHealthMe is studying from 1,272 Oracea users. Check the latest studies of Oracea.

On Jul, 10, 2026

29 people who take Profen and Oracea together, and have interactions are studied.

What are the common drug interactions of Profen and Oracea, by gender? *:

female:

Chronic kidney disease
Tremor (trembling or shaking movements in one or more parts of your body)
Blood pressure increased
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Somnolence (a state of near-sleep, a strong desire for sleep)
Alopecia (absence of hair from areas of the body)
Hair colour changes
Hair disorder

male:

Drug ineffective
Swelling
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Furuncle (infection of the hair follicle)
Hypersensitivity
Nausea (feeling of having an urge to vomit)
Nervousness
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)

What are the common drug interactions of Profen and Oracea, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abscess (pus)
Anxiety
Blood lactate dehydrogenase increased
Depression
Discomfort
Dizziness
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Furuncle (infection of the hair follicle)

30-39:

Asthenia (weakness)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Fatigue (feeling of tiredness)
Gallbladder injury
Memory impairment
Nausea (feeling of having an urge to vomit)

40-49:

Headache (pain in head)
Vulvovaginal burning sensation
Vulvovaginal discomfort
Vulvovaginal mycotic infection (vulvovaginal fungal infection)
Vulvovaginal pruritus (vulvovaginal severe itching)
Anxiety
Arrhythmia (irregular heartbeat)
Cardiac flutter (abnormal heart rhythm)
Feeling drunk
Lethargy (tiredness)

50-59:

Alopecia (absence of hair from areas of the body)
Hair colour changes
Hair disorder
Chronic kidney disease
Fungal infection
Perineal infection
Renal failure (kidney dysfunction)
Scar
Skin erosion (a discontinuity of the skin)

60+:

Chronic kidney disease
Tremor (trembling or shaking movements in one or more parts of your body)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nerve injury
Photosensitivity reaction
Quality of life decreased
Rash macular (small, flat red spots)
Rash papular (redness with papule)
Rash pruritic (redness with itching)
Tendonitis (a condition that causes pain and swelling of tendons)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 20.69%
Menopause (end of monthly cycles in women): 4 people, 13.79%
Ankylosing Spondylitis (type of arthritis affecting the spine): 4 people, 13.79%
Stress And Anxiety: 4 people, 13.79%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 13.79%
Depression: 4 people, 13.79%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 13.79%
Multiple Allergies (allergy to multiple agents): 4 people, 13.79%
Weight Decreased: 3 people, 10.34%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 10.34%

* Approximation only. Some reports may have incomplete information.

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