Profen and Probenecid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Probenecid (probenecid). Common drug interactions include cerebral infarction among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Probenecid. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Probenecid?

Probenecid has active ingredients of probenecid. It is often used in gout. eHealthMe is studying from 560 Probenecid users. Check the latest studies of Probenecid.

On Jul, 15, 2026

20 people who take Profen and Probenecid together, and have interactions are studied.

Profen and Probenecid drug interactions.

What are the common drug interactions of Profen and Probenecid, by gender? *:

female:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Coarctation of the aorta (narrowing of the part of aorta)
Maternal exposure during pregnancy (use of substance during pregnancy)
Mitral valve hypoplasia (mitral valves are either too small to allow sufficient blood)
Right ventricular hypertrophy (right ventricular enlargement)
Sepsis (a severe blood infection that can lead to organ failure and death)
Tricuspid valve incompetence (inefficient heart valve)
White blood cell count increased
Aggression
Agitation (state of anxiety or nervous excitement)

male:

Emotional distress
Anxiety
Decreased appetite
Delusion (a false belief or opinion)
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
General physical health deterioration (weak health status)
Joint contracture (a permanent shortening of a muscle or joint)
Myosclerosis (hardening of muscle tissue)

What are the common drug interactions of Profen and Probenecid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Aggression
Agitation (state of anxiety or nervous excitement)
Delusion (a false belief or opinion)
Depression
Hyperglycaemia (high blood sugar)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Suicidal ideation
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Dyspnoea (difficult or laboured respiration)
Feeling hot

50-59:

Vision blurred
Aggression
Agitation (state of anxiety or nervous excitement)
Anaemia (lack of blood)
Bicuspid aortic valve
Cerebral infarction (less blood supply to brain resulting tissue damage)
Coarctation of the aorta (narrowing of the part of aorta)
Delusion (a false belief or opinion)
Depression
Maternal exposure during pregnancy (use of substance during pregnancy)

60+:

Injury
Abasia (inability to walk)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pneumonia
Scar
Skin fibrosis (fibrous tissue formation on skin)
Skin induration (an abnormally hard spot or area on the skin)
Affective disorder (mental disorder)
Anxiety
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)

What are the existing conditions these people have? *

Joint Pain: 3 people, 15.00%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 15.00%
Hiv Infection: 3 people, 15.00%
High Blood Pressure: 3 people, 15.00%
Depression: 2 people, 10.00%
Stress And Anxiety: 2 people, 10.00%
Bipolar Disorder (mood disorder): 1 person, 5.00%
Blood Pressure Abnormal: 1 person, 5.00%
Back Pain - Low: 1 person, 5.00%
Immunodeficiency Disorders: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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