Profen and Sirolimus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Sirolimus (sirolimus). Common drug interactions include blood pressure increased among females and viith nerve injury among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Sirolimus. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Sirolimus?

Sirolimus has active ingredients of sirolimus. eHealthMe is studying from 11,823 Sirolimus users. Check the latest studies of Sirolimus.

On Jul, 15, 2026

60 people who take Profen and Sirolimus together, and have interactions are studied.

What are the common drug interactions of Profen and Sirolimus, by gender? *:

female:

Blood pressure increased
Fluid retention (an abnormal accumulation of fluid in the blood)
Headache (pain in head)
Muscle spasms (muscle contraction)
Bladder irritation
Chronic kidney disease
Fatigue (feeling of tiredness)
Myositis (inflammation of the muscles)
Oedema peripheral (superficial swelling)
Renal failure (kidney dysfunction)

male:

Viith nerve injury
Dysphagia (a condition in which swallowing is difficult or painful)
Epstein-barr virus infection
Gastroenteritis salmonella (inflammation of stomach and intestine caused by salmonella bacteria)
Upper respiratory tract infection
Enterocolitis bacterial
Human herpesvirus 6 infection
Varicella
Diarrhoea
Anaemia (lack of blood)

What are the common drug interactions of Profen and Sirolimus, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Infection
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)

10-19:

Viith nerve injury
Abdominal pain
Dysphagia (a condition in which swallowing is difficult or painful)
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Oral candidiasis (fungal infection of mouth)
Periorbital oedema (swelling around the eyes)
Somnolence (a state of near-sleep, a strong desire for sleep)
Stomatitis (inflammation of mucous membrane of mouth)
Adenovirus infection
Epstein-barr virus infection

20-29:

n/a

30-39:

Hyperkalaemia (damage to or disease of the kidney)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)
Anaemia (lack of blood)
Blood creatinine increased
Blood glucose increased
Blood urea increased
Body temperature increased
Diarrhoea
Glomerular filtration rate decreased

40-49:

Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Uveitis (inflammation of the uvea)
Chronic kidney disease
Glomerulonephritis minimal lesion (a disease of the kidney that causes nephrotic syndrome and usually affects children)
Liver transplant
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Renal failure (kidney dysfunction)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)

50-59:

Nausea (feeling of having an urge to vomit)
Neck pain
Surgery
Vertebral column mass (spinal tumour)
Vitamin b1 increased
Vomiting
Adverse drug reaction
Bell's palsy (facial paralysis)
Bruxism (habitual grinding of the teeth, typically during sleep)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

60+:

Generalised oedema (swelling all over the body)
Drug ineffective
Renal impairment (severely reduced kidney function)
Vascular occlusion (sudden blockage of a blood vessel, usually with a clot)
Affective disorder (mental disorder)
Anaemia (lack of blood)
Anxiety
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Aphasia (damage to the parts of the brain that control language)
Arthralgia (joint pain)

What are the existing conditions these people have? *

Immunodeficiency Disorders: 10 people, 16.67%
High Blood Pressure: 9 people, 15.00%
Oral Candidiasis (fungal infection of mouth): 8 people, 13.33%
Anaesthesia: 8 people, 13.33%
Chronic Graft Versus Host Disease (immune cells attack the host's body cells after transplant): 6 people, 10.00%
Lymphoproliferative Disorder (a medical condition in which the immune system makes too many white blood cells): 5 people, 8.33%
Infection: 5 people, 8.33%
Diarrhea: 4 people, 6.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 6.67%
Blood Calcium Decreased: 3 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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