Profen and Surmontil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Surmontil (trimipramine maleate). Common drug interactions include tooth loss among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Surmontil. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Surmontil?

Surmontil has active ingredients of trimipramine maleate. It is often used in insomnia. eHealthMe is studying from 693 Surmontil users. Check the latest studies of Surmontil.

On Jul, 10, 2026

18 people who take Profen and Surmontil together, and have interactions are studied.

What are the common drug interactions of Profen and Surmontil, by gender? *:

female:

Tooth loss
Cardiac arrest
Chronic kidney disease
Depressed mood
Endometrial hyperplasia (enlargement of uterus wall)
Epidermal necrosis (skin condition that is usually caused by a reaction to drugs)
Epstein-barr virus infection
Fall
Hepatic failure (liver failure)
Hyperkalaemia (damage to or disease of the kidney)

male:

Death
Arrhythmia (irregular heartbeat)
Blood pressure increased
Heart rate increased
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

What are the common drug interactions of Profen and Surmontil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Epidermal necrosis (skin condition that is usually caused by a reaction to drugs)
Epstein-barr virus infection
Hyperthermia (body temperature greatly above normal)
Odynophagia (painful swallowing, in the mouth (oropharynx) or oesophagus)
Parvovirus b19 serology positive
Toxic skin eruption (skin breakdown due to toxic substance)

30-39:

n/a

40-49:

Death
Depressed mood
Endometrial hyperplasia (enlargement of uterus wall)
Ovarian cyst (fluid filled sac of the ovary)
Papilloma viral infection
Sleep disorder
Uterine leiomyoma (uterine benign tumour derived from smooth muscle)

50-59:

Fall
Hepatic failure (liver failure)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

60+:

Constipation
Hypoglycaemia (deficiency of glucose in the bloodstream)
Chronic kidney disease
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypertension (high blood pressure)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Arrhythmia (irregular heartbeat)
Blood pressure increased

What are the existing conditions these people have? *

Depression: 4 people, 22.22%
Blood Follicle Stimulating Hormone Decreased: 3 people, 16.67%
Blood Luteinising Hormone Decreased: 3 people, 16.67%
Dermatitis Contact (skin reaction (dermatitis) resulting from exposure to allergens): 3 people, 16.67%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 3 people, 16.67%
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 3 people, 16.67%
Hypogonadism (reduction or absence of hormone secretion or other physiological activity of the gonads (testes or ovaries)): 3 people, 16.67%
Hypoglycemia (low blood sugar): 2 people, 11.11%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 5.56%
Headache (pain in head): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Profen and Surmontil?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously