Profen and Symbyax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Symbyax (fluoxetine hydrochloride; olanzapine). Common drug interactions include eyelid oedema among females and drug hypersensitivity among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Symbyax. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Symbyax?

Symbyax has active ingredients of fluoxetine hydrochloride; olanzapine. It is often used in depression. eHealthMe is studying from 1,449 Symbyax users. Check the latest studies of Symbyax.

On Jul, 06, 2026

42 people who take Profen and Symbyax together, and have interactions are studied.

What are the common drug interactions of Profen and Symbyax, by gender? *:

female:

Eyelid oedema (eyelids are swollen and contain excessive fluid)
Fall
Gait disturbance
Gastric ph decreased
Gastroenteritis (inflammation of stomach and intestine)
Glycosuria (excretion of glucose into the urine)
Glycosylated haemoglobin increased
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hepatitis a antibody positive
Hypercalcaemia (elevated calcium (ca+) level in the blood)

male:

Drug hypersensitivity
Arthralgia (joint pain)
Blood potassium decreased
Diarrhoea
Hypoglycaemia (deficiency of glucose in the bloodstream)
Intervertebral disc protrusion (spinal disc protrusion)
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Multiple drug overdose intentional
Nausea (feeling of having an urge to vomit)
Overdose

What are the common drug interactions of Profen and Symbyax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Anxiety
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Gastritis (inflammation of stomach)
Nausea (feeling of having an urge to vomit)
Post-traumatic stress disorder
Pregnancy on oral contraceptive
Procedural pain
Procedural vomiting

30-39:

Arthralgia (joint pain)
Compulsive shopping
Eating disorder
Hospitalisation
Nephrolithiasis (calculi in the kidneys)
Weight increased
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Agitation (state of anxiety or nervous excitement)
Blood cholesterol increased

40-49:

Vision blurred
White blood cell count increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Fatigue (feeling of tiredness)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Blood cholesterol increased
Cough
Dyspnoea (difficult or laboured respiration)

50-59:

Abdominal discomfort
Anxiety
Arthralgia (joint pain)
Diarrhoea
Fear
Gastric ph decreased
Gastritis (inflammation of stomach)
Headache (pain in head)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hysterectomy

60+:

Drug hypersensitivity
Abdominal pain
Fear
Gait disturbance
Headache (pain in head)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Muscular weakness (muscle weakness)
Pain in extremity
Peripheral swelling
Blood potassium decreased

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 15 people, 35.71%
Stress And Anxiety: 14 people, 33.33%
High Blood Cholesterol: 7 people, 16.67%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 5 people, 11.90%
Insomnia (sleeplessness): 5 people, 11.90%
Inflammation: 5 people, 11.90%
Infection: 5 people, 11.90%
Erection Problems: 4 people, 9.52%
Affective Disorder (mental disorder): 4 people, 9.52%
Dyspnea (difficult or laboured breathing): 4 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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