Profen and Trusopt drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Trusopt (dorzolamide hydrochloride). Common drug interactions include blindness among females and melaena among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Trusopt. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Trusopt?

Trusopt has active ingredients of dorzolamide hydrochloride. It is often used in glaucoma. eHealthMe is studying from 3,165 Trusopt users. Check the latest studies of Trusopt.

On Jul, 26, 2026

28 people who take Profen and Trusopt together, and have interactions are studied.

What are the common drug interactions of Profen and Trusopt, by gender? *:

female:

Blindness
Dyspnoea (difficult or laboured respiration)
Abasia (inability to walk)
Antinuclear antibody positive
Balance disorder
Blood creatinine increased
Blood urea increased
Blood uric acid increased
Depression
Dizziness

male:

Melaena (the passage of black, tarry stools)
Peptic ulcer
Arthralgia (joint pain)
Bleeding time prolonged
Death
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Duodenitis (inflammation of the duodenum)
Electrocardiogram repolarisation abnormality
Fatigue (feeling of tiredness)
Haematochezia (passage of stools containing blood)

What are the common drug interactions of Profen and Trusopt, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Dysphoria (generalized dissatisfaction with life)
Gallbladder injury
Oropharyngeal discomfort (pain or irritation of oropharynx)
Palpitations (feelings or sensations that your heart is pounding or racing)

50-59:

Abasia (inability to walk)
Antinuclear antibody positive
Balance disorder
Blindness
Blood creatinine increased
Blood urea increased
Blood uric acid increased
Dizziness
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)

60+:

Melaena (the passage of black, tarry stools)
Peptic ulcer
Nausea (feeling of having an urge to vomit)
Proctitis ulcerative (inflammation of the rectum and anus ulcerative)
Renal failure (kidney dysfunction)
Hypotension (abnormally low blood pressure)
Infusion site pain
Loss of consciousness
Abdominal pain
Alopecia (absence of hair from areas of the body)

What are the existing conditions these people have? *

High Blood Pressure: 10 people, 35.71%
Hypersensitivity: 7 people, 25.00%
High Blood Cholesterol: 7 people, 25.00%
Platelet Aggregation Inhibition: 6 people, 21.43%
Enlarged Prostate: 6 people, 21.43%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 10.71%
Intraocular Pressure Increased: 2 people, 7.14%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 2 people, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.14%
Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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