Profen and Valeriana drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Valeriana (valerian). Common drug interactions include alanine aminotransferase increased among females and alcohol abuse among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Valeriana. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,312 Profen users. Check the latest studies of Profen.

What is Valeriana?

Valeriana has active ingredients of valerian. eHealthMe is studying from 460 Valeriana users. Check the latest studies of Valeriana.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

47 people who take Profen and Valeriana together, and have interactions are studied.

What are the common drug interactions of Profen and Valeriana, by gender? *:

female:

Alanine aminotransferase increased
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety disorder
Arthropathy
Atrial tachycardia (rhythm disturbance that arises in the atria)
Blood iron decreased
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cartilage injury
Catheter site erythema (redness of skin at catheter site)

male:

Alcohol abuse
Drug abuse
Drug level increased
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Hangover
Malaise (a feeling of general discomfort or uneasiness)
Muscular weakness (muscle weakness)
Nasopharyngitis (inflammation of the nasopharynx)
Nocturia (the need to get up in the night to urinate)
Oropharyngeal pain

What are the common drug interactions of Profen and Valeriana, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Confusional state
Mydriasis (a dilation of the pupil)
Slow speech

20-29:

Anxiety
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Decreased appetite
Depression
Dizziness
Fear
Mydriasis (a dilation of the pupil)
Nausea (feeling of having an urge to vomit)
Panic attack
Panic reaction

30-39:

Overdose
Renal tubular necrosis (death of kidney tubules)
Renal failure (kidney dysfunction)
Abscess limb (limb infection)
Adrenal disorder
Cellulitis (infection under the skin)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Fall
Fluid overload (too much fluid in the blood)

40-49:

Sinusitis (inflammation of sinus)

50-59:

Surgery

60+:

Abnormal weight gain
Anxiety
Cataract (clouding of the lens inside the eye)
Catheter site erythema (redness of skin at catheter site)
Diarrhoea
Drug eruption (adverse drug reaction of the skin)
Abdominal discomfort
Appendix disorder
Ataxia (loss of full control of bodily movements)
Blood sodium decreased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 19.15%
Joint Pain: 7 people, 14.89%
Headache (pain in head): 7 people, 14.89%
Fibromyalgia (a long-term condition which causes pain all over the body): 7 people, 14.89%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 10.64%
Back Pain: 5 people, 10.64%
Immunodeficiency Common Variable: 3 people, 6.38%
Breast Cancer: 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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