Profen and Zemplar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Zemplar (paricalcitol). Common drug interactions include anxiety among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Zemplar. It is created by eHealthMe based on reports of 88 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Zemplar?

Zemplar has active ingredients of paricalcitol. It is often used in kidney disease. eHealthMe is studying from 15,494 Zemplar users. Check the latest studies of Zemplar.

On Aug, 01, 2026

88 people who take Profen and Zemplar together, and have interactions are studied.

What are the common drug interactions of Profen and Zemplar, by gender? *:

female:

Anxiety
Asthenia (weakness)
Oedema peripheral (superficial swelling)
Renal failure chronic (long lasting kidney dysfunction)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Mobility decreased (ability to move is reduced)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Quality of life decreased
Skin tightness
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Chest pain
Cough
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)
Fall
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Infectious peritonitis (inflammation of the peritoneum, typically caused by bacterial infection)
Renal impairment (severely reduced kidney function)

What are the common drug interactions of Profen and Zemplar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)

30-39:

n/a

40-49:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Cough
Decreased appetite
Dyspepsia (indigestion)
Dysphagia (a condition in which swallowing is difficult or painful)
Ear pain
Headache (pain in head)
Hypersensitivity

50-59:

Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Joint range of motion decreased (disease of joint movement)
Mobility decreased (ability to move is reduced)
Muscle tightness
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Oedema peripheral (superficial swelling)
Quality of life decreased
Skin tightness
Fatigue (feeling of tiredness)
Skin discolouration (change of skin colour)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
General physical health deterioration (weak health status)
Renal failure chronic (long lasting kidney dysfunction)
Abdominal pain
Anaemia (lack of blood)
Asthenia (weakness)
Blood bicarbonate decreased
Blood glucose increased
Blood sodium decreased

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 33 people, 37.50%
High Blood Cholesterol: 24 people, 27.27%
Gout (uric acid crystals building up in the body): 21 people, 23.86%
High Blood Pressure: 20 people, 22.73%
Diabetes: 15 people, 17.05%
Cardiac Disorder: 10 people, 11.36%
Infection: 8 people, 9.09%
Nuclear Magnetic Resonance Imaging Abdominal: 8 people, 9.09%
Gastric Ulcer (stomach ulcer): 8 people, 9.09%
Fluid Retention (an abnormal accumulation of fluid in the blood): 7 people, 7.95%

* Approximation only. Some reports may have incomplete information.

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