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Profen and Zenatane drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Zenatane (isotretinoin). Common drug interactions include arthralgia among females and dry skin among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Zenatane. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Zenatane?

Zenatane has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 5,688 Zenatane users. Check the latest studies of Zenatane.

On Jul, 21, 2026

17 people who take Profen and Zenatane together, and have interactions are studied.

Profen and Zenatane drug interactions.

What are the common drug interactions of Profen and Zenatane, by gender? *:

female:

  1. Arthralgia (joint pain)
  2. Nephrolithiasis (calculi in the kidneys)
  3. Inflammatory bowel disease
  4. Asthma exercise induced
  5. Colitis (inflammation of colon)
  6. Depression
  7. Fibromyalgia (a long-term condition which causes pain all over the body)
  8. Haematochezia (passage of stools containing blood)
  9. Polyp
  10. Selective abortion (selected abortion)

male:

  1. Dry skin
  2. Lip dry
  3. Affective disorder (mental disorder)
  4. Blood triglycerides increased
  5. Epistaxis (bleed from the nose)
  6. Fatigue (feeling of tiredness)
  7. Erythema (redness of the skin)
  8. Lip swelling
  9. Rash
  10. Rash pruritic (redness with itching)

What are the common drug interactions of Profen and Zenatane, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Lip dry
  2. Colitis (inflammation of colon)
  3. Haematochezia (passage of stools containing blood)
  4. Polyp
  5. Abdominal discomfort
  6. Dyspepsia (indigestion)
  7. Erythema (redness of the skin)
  8. Headache (pain in head)
  9. Rash pruritic (redness with itching)
  10. Vomiting

20-29:

  1. Arthralgia (joint pain)
  2. Tendon pain

30-39:

  1. Selective abortion (selected abortion)

40-49:

  1. Arthralgia (joint pain)
  2. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 11.76%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 11.76%
  3. Birth Control: 2 people, 11.76%
  4. Sinusitis (inflammation of sinus): 1 person, 5.88%
  5. Migraine (headache): 1 person, 5.88%
  6. Lip Disorder (disease of lip): 1 person, 5.88%
  7. Cough: 1 person, 5.88%
  8. Acne Cystic (skin problems that cause pimples): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Profen and Zenatane?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Profen and Zenatane:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Profen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zenatane:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Profen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zenatane and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen and isotretinoin (the active ingredients of Profen and Zenatane, respectively), and Profen and Zenatane (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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