Prograf and Hydrocodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prograf (tacrolimus) and Hydrocodone (hydrocodone bitartrate; ibuprofen). Common drug interactions include cyanosis among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Prograf and Hydrocodone. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Prograf?

Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 42,230 Prograf users. Check the latest studies of Prograf.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

On Jul, 07, 2026

18 people who take Prograf and Hydrocodone together, and have interactions are studied.

Prograf and Hydrocodone drug interactions.

What are the common drug interactions of Prograf and Hydrocodone, by gender? *:

female:

Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Drug abuse
Cardiac failure congestive
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Chronic kidney disease
Hypoxia (low oxygen in tissues)
Infection
Influenza
Purulent discharge (discharge that contains pus)
Renal failure (kidney dysfunction)

male:

Pain
Anal abscess
Fatigue (feeling of tiredness)
Gait disturbance
Genital abscess (build up of pus in genital)
Gout (uric acid crystals building up in the body)
Hypokalaemia (low potassium)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Nephrogenic anaemia (anaemia due to kidney disease)

What are the common drug interactions of Prograf and Hydrocodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Drug abuse

30-39:

n/a

40-49:

Anal abscess
Pain
Anal fistula
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Carbuncle (a carbuncle is an abscess larger than a boil)
Chronic kidney disease
Emotional distress
Fatigue (feeling of tiredness)
Gait disturbance

50-59:

Hypokalaemia (low potassium)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nephrogenic anaemia (anaemia due to kidney disease)
Pain
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Nephrogenic anaemia (anaemia due to kidney disease)

What are the existing conditions these people have? *

Pain: 4 people, 22.22%
Indigestion: 4 people, 22.22%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 22.22%
Hepatitis C: 3 people, 16.67%
Multiple Allergies (allergy to multiple agents): 3 people, 16.67%
Infection: 3 people, 16.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 16.67%
Diabetes: 3 people, 16.67%
High Blood Pressure: 3 people, 16.67%
General Physical Health Deterioration (weak health status): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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