Prolensa and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prolensa (bromfenac sodium) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include cataract among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Prolensa and Benadryl. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Prolensa?

Prolensa has active ingredients of bromfenac sodium. eHealthMe is studying from 1,170 Prolensa users. Check the latest studies of Prolensa.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

On Jul, 10, 2026

24 people who take Prolensa and Benadryl together, and have interactions are studied.

Prolensa and Benadryl drug interactions.

What are the common drug interactions of Prolensa and Benadryl, by gender? *:

female:

Cataract (clouding of the lens inside the eye)
Catheter site erythema (redness of skin at catheter site)
Infusion site pain
Tooth disorder (tooth disease)
Arthralgia (joint pain)
Erythema (redness of the skin)
Hereditary angioedema (recurrent episodes of severe swelling)
Hypersensitivity
Rash papular (redness with papule)
Vein disorder

male:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Renal failure (kidney dysfunction)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypertension (high blood pressure)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal injury (kidney injury)

What are the common drug interactions of Prolensa and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Rash
Cataract (clouding of the lens inside the eye)
Rash papular (redness with papule)
Renal failure (kidney dysfunction)
Vein disorder
Headache (pain in head)
Contusion (a type of hematoma of tissue in which capillaries)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
General physical health deterioration (weak health status)
Infusion site bruising

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 9 people, 37.50%
High Blood Cholesterol: 6 people, 25.00%
High Blood Pressure: 5 people, 20.83%
Immune System Disorder: 4 people, 16.67%
Pain: 4 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 16.67%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 4 people, 16.67%
Multiple Allergies (allergy to multiple agents): 4 people, 16.67%
Glaucoma (increased fluid pressure in the eye with vision loss): 4 people, 16.67%
Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 4 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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