Proleukin and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Proleukin (aldesleukin) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include hypokalaemia among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Proleukin and Benadryl. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Proleukin?

Proleukin has active ingredients of aldesleukin. eHealthMe is studying from 1,865 Proleukin users. Check the latest studies of Proleukin.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

On Jul, 12, 2026

62 people who take Proleukin and Benadryl together, and have interactions are studied.

Proleukin and Benadryl drug interactions.

What are the common drug interactions of Proleukin and Benadryl, by gender? *:

female:

Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Malaise (a feeling of general discomfort or uneasiness)
Pupil fixed
Rigors (an episode of shaking or exaggerated shivering)
Alpha haemolytic streptococcal infection (infections with alpha-haemolytic strep bacteria are common; many strains live naturally in humans)
Blood culture positive
Diarrhoea
Dysarthria (speech disorder)
Enterobacter bacteraemia (enterobacter cloacae are nosocomial pathogens that can cause a range of infections such as bacteraemia, lower respiratory tract infection, skin)

male:

Fatigue (feeling of tiredness)
Pyrexia (fever)
Anaemia (lack of blood)
Cardiogenic shock (inadequate circulation of blood)
Chest pain
Coma (state of unconsciousness lasting more than six hours)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Heart rate increased

What are the common drug interactions of Proleukin and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Hypokalaemia (low potassium)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)

10-19:

n/a

20-29:

Pyrexia (fever)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Arthralgia (joint pain)
Catheter related complication
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Erythema nodosum (skin inflammation that results in reddish, painful, tender lumps most commonly located in the front of the legs below)
Febrile neutropenia (fever with reduced white blood cells)
Haemoglobin decreased
Hypokalaemia (low potassium)

30-39:

Influenza like illness
Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Vomiting
Dyspnoea (difficult or laboured respiration)
Rash pruritic (redness with itching)
Urticaria (rash of round, red welts on the skin that itch intensely)

40-49:

Coma (state of unconsciousness lasting more than six hours)
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Cardiogenic shock (inadequate circulation of blood)
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Pyrexia (fever)
Renal failure acute (rapid kidney dysfunction)
Vomiting
Anaemia (lack of blood)

50-59:

Electrocardiogram abnormal
Embolic stroke (stroke due to obstruction due to an embolus)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Eye rolling
Facial palsy (paralysis of face nerve)
Fatigue (feeling of tiredness)
Haematemesis (vomiting of blood)
Haematocrit decreased
Haematuria (presence of blood in urine)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)

60+:

Fatigue (feeling of tiredness)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Coma (state of unconsciousness lasting more than six hours)
Enterobacter bacteraemia (enterobacter cloacae are nosocomial pathogens that can cause a range of infections such as bacteraemia, lower respiratory tract infection, skin)
Haemoglobin decreased
Hypoxia (low oxygen in tissues)
Klebsiella bacteraemia (klebsiella bacteria in blood after infection to lungs)
Platelet count decreased
Pleural effusion (water on the lungs)
Pupil fixed

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 8 people, 12.90%
Renal Cell Carcinoma Stage Unspecified (kidney cancer in unknown stage): 4 people, 6.45%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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