Proleukin and Combivir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Proleukin (aldesleukin) and Combivir (lamivudine; zidovudine). Common drug interactions include pyrexia among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Proleukin and Combivir. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Proleukin?

Proleukin has active ingredients of aldesleukin. eHealthMe is studying from 1,865 Proleukin users. Check the latest studies of Proleukin.

What is Combivir?

Combivir has active ingredients of lamivudine; zidovudine. It is often used in hiv infection. eHealthMe is studying from 15,450 Combivir users. Check the latest studies of Combivir.

On Jul, 09, 2026

24 people who take Proleukin and Combivir together, and have interactions are studied.

Proleukin and Combivir drug interactions.

What are the common drug interactions of Proleukin and Combivir, by gender? *:

female:

Pyrexia (fever)
Aphasia (damage to the parts of the brain that control language)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Confusion
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Encephalitis (inflammation of the brain)
Fatigue (feeling of tiredness)
Lethargy (tiredness)

male:

Abdominal pain
Blood amylase increased
Blood triglycerides increased
Cardiac failure congestive
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Ejection fraction (the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat)
Electrocardiogram abnormal
Electrocardiogram st segment elevation
Hypoaesthesia (reduced sense of touch or sensation)
Influenza like illness

What are the common drug interactions of Proleukin and Combivir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Flatulence (flatus expelled through the anus)
Food poisoning (poison in food)
Gastric erosions (gradual destruction of surface layer of the membrane lining the stomach)
Heart rate increased
Injection site erythema (redness at injection site)
Lethargy (tiredness)
Loss of consciousness
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Metabolic disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues)

40-49:

Blood triglycerides increased
Cardiac failure congestive
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Ejection fraction (the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat)
Electrocardiogram abnormal
Electrocardiogram st segment elevation
Gamma-glutamyltransferase increased
Hypoaesthesia (reduced sense of touch or sensation)
Mitral valve incompetence (inefficient heart valve)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)

50-59:

Abdominal pain
Blood amylase increased
Weight decreased
Abdominal mass (localized enlargement or swelling in the human abdomen)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Asthenia (weakness)
Blood alkaline phosphatase increased
Blood bilirubin increased
Cd8 lymphocytes increased
Cytolytic hepatitis (dissolution or destruction of a liver cell)

60+:

n/a

What are the existing conditions these people have? *

Hiv Infection: 9 people, 37.50%
High Blood Pressure: 2 people, 8.33%
Hepatitis Viral: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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