Hctz and Emphysema - a phase IV clinical study of FDA data

Summary:

Emphysema is reported as a side effect among people who take Hctz (hydrochlorothiazide), especially for people who are female, 60+ old, also take Symbicort, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Emphysema when taking Hctz. It is created by eHealthMe based on reports of 23,493 people who have side effects when taking Hctz from the FDA, and is updated regularly.

What is Hctz?

Hctz has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 24,823 Hctz users. Check the latest studies of Hctz.

What is Emphysema?

Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs) is found to be associated with 1,079 drugs and 1,096 conditions by eHealthMe. Check the latest studies of Emphysema.

On Jul, 09, 2026

23,493 people reported to have side effects when taking Hctz.
Among them, 20 people (0.09%) have Emphysema.

Among these 20 people:

What is the gender of people who have Emphysema when taking Hctz? *

female: 57.89 %
male: 42.11 %

What is the age of people who have Emphysema when taking Hctz? *

What are other drugs people take besides Hctz? *

What are other side effects people have besides Emphysema? *

Dyspnea (difficult or laboured breathing): 6 people, 30.00%
Pneumonia: 6 people, 30.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 6 people, 30.00%
Insomnia (sleeplessness): 5 people, 25.00%
Malaise (a feeling of general discomfort or uneasiness): 5 people, 25.00%
Chest Pain: 4 people, 20.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 20.00%
Visual Acuity Reduced (reduced clearness of vision): 3 people, 15.00%
Agitation (state of anxiety or nervous excitement): 3 people, 15.00%
Nasopharyngitis (inflammation of the nasopharynx): 3 people, 15.00%

What are the existing conditions these people have? *

Stress And Anxiety: 6 people, 30.00%
Depression: 6 people, 30.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 30.00%
Sleep Disorder: 5 people, 25.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 20.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 20.00%
Pain: 4 people, 20.00%
Asthma: 3 people, 15.00%
Blood Pressure Abnormal: 3 people, 15.00%
Muscle Spasms (muscle contraction): 3 people, 15.00%

* Approximation only. Some reports may have incomplete information.

Do you take Hctz and have Emphysema?

- Check whether Emphysema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hctz:

Hctz (24,823 reports)

Emphysema treatments and more:

Emphysema (29,685 reports)

Browse all side effects of Hctz:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Emphysema:

Emphysema (1,079 drugs)

Browse all the conditions that are associated with Emphysema:

Emphysema (1,096 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Hctz) and Hctz (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.