Prolia and Buscopan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prolia (denosumab) and Buscopan (hyoscine butylbromide). Common drug interactions include arthralgia among females and chronic obstructive pulmonary disease among males.

The phase IV clinical study analyzes what interactions people have when they take Prolia and Buscopan. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,389 Prolia users. Check the latest studies of Prolia.

What is Buscopan?

Buscopan has active ingredients of hyoscine butylbromide. eHealthMe is studying from 4,828 Buscopan users. Check the latest studies of Buscopan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

18 people who take Prolia and Buscopan together, and have interactions are studied.

What are the common drug interactions of Prolia and Buscopan, by gender? *:

female:

Arthralgia (joint pain)
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal pain
Arthropathy
Asthenia (weakness)
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cough
Diarrhoea
Drug hypersensitivity

male:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Compression fracture (fracture due to pressure caused by injury)
Lower respiratory tract infection
Pyrexia (fever)

What are the common drug interactions of Prolia and Buscopan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Pyelonephritis (inflammation of kidney caused by bacteria)

40-49:

Pruritus (severe itching of the skin)
Rash
Sneezing
Throat irritation
Throat tightness
Tinnitus (a ringing in the ears)
Toothache (tooth pain)
Tremor (trembling or shaking movements in one or more parts of your body)
Urticaria (rash of round, red welts on the skin that itch intensely)
Visual impairment

50-59:

Back pain
Cough
Cyanosis central (circulatory or ventilatory problem that leads to poor blood oxygenation in body)
Oropharyngeal pain

60+:

Malaise (a feeling of general discomfort or uneasiness)
Pain
Fall
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Limb injury
Low density lipoprotein increased (cholesterol increased in blood)
Nausea (feeling of having an urge to vomit)
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Spinal column stenosis (narrowing of spinal column)
Tremor (trembling or shaking movements in one or more parts of your body)

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 27.78%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 5 people, 27.78%
Birth Control: 3 people, 16.67%
Laxative Supportive Care: 3 people, 16.67%
Abdominal Pain: 3 people, 16.67%
Constipation: 3 people, 16.67%
High Blood Pressure: 3 people, 16.67%
Insomnia (sleeplessness): 2 people, 11.11%
Gastritis (inflammation of stomach): 2 people, 11.11%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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