Prolia and Combipatch drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prolia (denosumab) and Combipatch (estradiol; norethindrone acetate). Common drug interactions include pain among females.

The phase IV clinical study analyzes what interactions people have when they take Prolia and Combipatch. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,388 Prolia users. Check the latest studies of Prolia.

What is Combipatch?

Combipatch has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 3,599 Combipatch users. Check the latest studies of Combipatch.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 18, 2026

12 people who take Prolia and Combipatch together, and have interactions are studied.

Prolia and Combipatch drug interactions.

What are the common drug interactions of Prolia and Combipatch, by gender? *:

female:

Pain
Cystitis (inflammation of the wall of the bladder)
Gingival bleeding (bleeding gums)
Hepatic enzyme increased
Injection site bruising
Injection site mass
Loose tooth
Urinary tract infection
Vomiting
Arthralgia (joint pain)

male:

n/a

What are the common drug interactions of Prolia and Combipatch, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest pain
Cough
Injection site pain

30-39:

n/a

40-49:

n/a

50-59:

Pain
Cystitis (inflammation of the wall of the bladder)
Intervertebral disc protrusion (spinal disc protrusion)
Nausea (feeling of having an urge to vomit)
Urinary bladder haemorrhage (urinary bladder bleeding)
Blood magnesium decreased
Blood urine present
Gingival bleeding (bleeding gums)
Hepatic enzyme increased
Loose tooth

60+:

Bone density decreased
Injection site bruising
Dehydration (dryness resulting from the removal of water)
Dizziness
Drug hypersensitivity
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)

What are the existing conditions these people have? *

Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 6 people, 50.00%
Urinary Tract Infection: 2 people, 16.67%
Skin Infection: 2 people, 16.67%
Bacterial Infection: 2 people, 16.67%
Birth Control: 2 people, 16.67%
Bone Density Decreased: 2 people, 16.67%
Cough: 2 people, 16.67%
Cystitis Interstitial (unknown cause characterized by bladder pain): 2 people, 16.67%
Depression: 2 people, 16.67%
Eye Infection: 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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