Prolia and Estring drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prolia (denosumab) and Estring (estradiol). Common drug interactions include fungal infection among females.

The phase IV clinical study analyzes what interactions people have when they take Prolia and Estring. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,388 Prolia users. Check the latest studies of Prolia.

What is Estring?

Estring has active ingredients of estradiol. eHealthMe is studying from 5,474 Estring users. Check the latest studies of Estring.

On Aug, 11, 2026

48 people who take Prolia and Estring together, and have interactions are studied.

What are the common drug interactions of Prolia and Estring, by gender? *:

female:

Fungal infection
Myalgia (muscle pain)
Asthma
Burning sensation
Cystitis (inflammation of the wall of the bladder)
Ear infection
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Fatigue (feeling of tiredness)
Fracture
Haemorrhage (bleeding)

male:

n/a

What are the common drug interactions of Prolia and Estring, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Influenza like illness
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nephrolithiasis (calculi in the kidneys)
Perinephric effusion (connective and fatty tissue surrounding a kidney)
Pleural effusion (water on the lungs)
Renal failure acute (rapid kidney dysfunction)
Renal haematoma (blood collection in kidney)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Asthma
Dyspnoea (difficult or laboured respiration)

60+:

Fungal infection
Skin disorder (skin disease)
Fracture
Haemorrhage (bleeding)
Hair disorder
Loss of consciousness
Multiple allergies (allergy to multiple agents)
Nail disorder (disease of nail)
Sinusitis (inflammation of sinus)
Sneezing

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 18.75%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 18.75%
Depression: 6 people, 12.50%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 10.42%
Immunodeficiency Common Variable: 5 people, 10.42%
Vulvovaginal Dryness: 4 people, 8.33%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 8.33%
Pain: 3 people, 6.25%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 3 people, 6.25%
Asthma: 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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