Prolia and Fluoride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prolia (denosumab) and Fluoride (fluoride). Common drug interactions include asthma among females and back disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Prolia and Fluoride. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,389 Prolia users. Check the latest studies of Prolia.

What is Fluoride?

Fluoride has active ingredients of fluoride. eHealthMe is studying from 2,301 Fluoride users. Check the latest studies of Fluoride.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

16 people who take Prolia and Fluoride together, and have interactions are studied.

What are the common drug interactions of Prolia and Fluoride, by gender? *:

female:

Asthma
Burning sensation
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Heart rate irregular
Hypoaesthesia (reduced sense of touch or sensation)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Infection
Influenza
Jaw disorder (jaw disease)

male:

Back disorder
Chills (felling of cold)
Peripheral swelling
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Capillary leak syndrome (capillary leaks plasma)
Cardiac murmur (an heart sound in valve abnormality)
Epistaxis (bleed from the nose)
Fall
Fatigue (feeling of tiredness)

What are the common drug interactions of Prolia and Fluoride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Asthma
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Heart rate irregular
Infection
Influenza
Pneumonia
Pyrexia (fever)
Sinusitis (inflammation of sinus)
Upper airway obstruction

50-59:

Burning sensation
Hypoaesthesia (reduced sense of touch or sensation)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Mobility decreased (ability to move is reduced)
Muscle spasms (muscle contraction)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Neck pain
Pain in jaw
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Abdominal pain

60+:

Fall
Jaw disorder (jaw disease)
Delirium (wild excitement)
Depressed level of consciousness
Dizziness
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Essential hypertension (primary hypertension)
General physical health deterioration (weak health status)
Hyperlipidaemia (presence of excess lipids in the blood)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 4 people, 25.00%
Humoral Immune Defect (impairment of humoral immunity): 4 people, 25.00%
Cough: 3 people, 18.75%
Asthma: 2 people, 12.50%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 2 people, 12.50%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 12.50%
Gait Disturbance: 2 people, 12.50%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 12.50%
Vein Disorder: 1 person, 6.25%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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