Prolixin and Nexium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prolixin (fluphenazine hydrochloride) and Nexium (esomeprazole magnesium). Common drug interactions include malaise among females and type 2 diabetes mellitus among males.

The phase IV clinical study analyzes what interactions people have when they take Prolixin and Nexium. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Prolixin?

Prolixin has active ingredients of fluphenazine hydrochloride. It is often used in schizoaffective disorder. eHealthMe is studying from 1,262 Prolixin users. Check the latest studies of Prolixin.

What is Nexium?

Nexium has active ingredients of esomeprazole magnesium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 245,677 Nexium users. Check the latest studies of Nexium.

On Jul, 10, 2026

19 people who take Prolixin and Nexium together, and have interactions are studied.

What are the common drug interactions of Prolixin and Nexium, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Obesity (having too much body fat)
Overweight
Pulmonary oedema (fluid accumulation in the lungs)
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Suicidal ideation
Depression
Agitation (state of anxiety or nervous excitement)
Anxiety

male:

Type 2 diabetes mellitus
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cow's milk intolerance (milk allergy)
Dyspepsia (indigestion)
Dysphagia (a condition in which swallowing is difficult or painful)
Malaise (a feeling of general discomfort or uneasiness)
Pain
Retching (strong involuntary effort to vomit)
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Throat irritation

What are the common drug interactions of Prolixin and Nexium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Bipolar disorder (mood disorder)
Cow's milk intolerance (milk allergy)
Dyspepsia (indigestion)
Dysphagia (a condition in which swallowing is difficult or painful)
Malaise (a feeling of general discomfort or uneasiness)
Pain
Retching (strong involuntary effort to vomit)
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Throat irritation
Vomiting

30-39:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Dyslipidaemia (abnormal amount of lipids)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hypertension (high blood pressure)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Obesity (having too much body fat)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Tooth abscess (pus formation in tooth)
Type 2 diabetes mellitus
Alcohol abuse

40-49:

Type 2 diabetes mellitus
Agitation (state of anxiety or nervous excitement)
Anxiety
Cardiac disorder
Depressed mood
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hot flush (sudden feelings of heat)
Hypertensive cardiomyopathy (heart disease caused by high blood pressure)
Malaise (a feeling of general discomfort or uneasiness)
Mood swings (an extreme or rapid change in mood)

50-59:

Contusion (a type of hematoma of tissue in which capillaries)
Depression
Fall
Insomnia (sleeplessness)
Joint effusion (presence of extra fluid in joint covering)
Muscle spasms (muscle contraction)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)
Osteoporosis (bones weak and more likely to break)
Panic reaction
Psychogenic pain disorder

60+:

Anaemia (lack of blood)
Dyspnoea (difficult or laboured respiration)
Gastrointestinal angiodysplasia (a small vascular malformation of the gut)
Pulmonary oedema (fluid accumulation in the lungs)

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 9 people, 47.37%
Depression: 9 people, 47.37%
Sleep Disorder: 6 people, 31.58%
Pain: 4 people, 21.05%
Stress And Anxiety: 3 people, 15.79%
Thyroid Diseases: 3 people, 15.79%
Discomfort: 2 people, 10.53%
Affective Disorder (mental disorder): 2 people, 10.53%
Psychotic Disorder: 2 people, 10.53%
Agitation (state of anxiety or nervous excitement): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

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