Promacta and Centrum silver drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promacta (eltrombopag olamine) and Centrum silver (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e). Common drug interactions include visual impairment among females and atrial fibrillation among males.

The phase IV clinical study analyzes what interactions people have when they take Promacta and Centrum silver. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Promacta?

Promacta has active ingredients of eltrombopag olamine. It is often used in idiopathic thrombocytopenic purpura (itp). eHealthMe is studying from 17,758 Promacta users. Check the latest studies of Promacta.

What is Centrum silver?

Centrum silver has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 19,997 Centrum silver users. Check the latest studies of Centrum silver.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

15 people who take Promacta and Centrum silver together, and have interactions are studied.

Promacta and Centrum silver drug interactions.

What are the common drug interactions of Promacta and Centrum Silver, by gender? *:

female:

Visual impairment
Vitreous floaters (spots before the eyes)
Headache (pain in head)
Diarrhoea
Pain in extremity
Visual acuity reduced (reduced clearness of vision)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Back pain
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Bone marrow plasmacyte count increased

male:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Fall
Fluid overload (too much fluid in the blood)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Haemorrhage (bleeding)
Hospitalisation
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Injury
Ligament sprain (ligament stretched)

What are the common drug interactions of Promacta and Centrum Silver, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Tremor (trembling or shaking movements in one or more parts of your body)
Weight decreased
Ageusia (loss of taste functions of the tongue)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Compression fracture (fracture due to pressure caused by injury)
Decreased appetite
Dry mouth
Dysgeusia (disorder of the sense of taste)

50-59:

n/a

60+:

Diarrhoea
Headache (pain in head)
Back pain
Bacteraemia (presence of bacteria in the blood)
Bacterial test positive
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Bone marrow plasmacyte count increased
Bone marrow reticulin fibrosis (thickening and scarring of bone marrow reticulin)
Cardiac murmur (an heart sound in valve abnormality)
Constipation

What are the existing conditions these people have? *

Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 4 people, 26.67%
Zinc Deficiency: 1 person, 6.67%
Thrombocytopenia (decrease of platelets in blood): 1 person, 6.67%
Multiple Myeloma (cancer of the plasma cells): 1 person, 6.67%
Kidney Stones: 1 person, 6.67%
Joint Pain: 1 person, 6.67%
Intestinal Obstruction: 1 person, 6.67%
Insomnia (sleeplessness): 1 person, 6.67%
Hyperparathyroidism Secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary): 1 person, 6.67%
High Blood Pressure: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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