Promethazine w/ codeine and Dilaudid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine w/ codeine (codeine phosphate; promethazine hydrochloride) and Dilaudid (hydromorphone hydrochloride). Common drug interactions include presyncope among females and actinomycosis among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine w/ codeine and Dilaudid. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine w/ codeine?

Promethazine w/ codeine has active ingredients of codeine phosphate; promethazine hydrochloride. It is often used in cough. eHealthMe is studying from 279 Promethazine w/ codeine users. Check the latest studies of Promethazine w/ codeine.

What is Dilaudid?

Dilaudid has active ingredients of hydromorphone hydrochloride. It is often used in pain. eHealthMe is studying from 96,466 Dilaudid users. Check the latest studies of Dilaudid.

On Jul, 17, 2026

18 people who take Promethazine w/ codeine and Dilaudid together, and have interactions are studied.

Promethazine w/ codeine and Dilaudid drug interactions.

What are the common drug interactions of Promethazine W/ Codeine and Dilaudid, by gender? *:

female:

Presyncope
Renal failure (kidney dysfunction)
Sinusitis (inflammation of sinus)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Tuberculin test positive
Uterine cancer
Abdominal pain upper
Atelectasis (partial or complete collapse of the lung)
Blood cholesterol increased
Blood glucose increased

male:

Actinomycosis (infection that causes sores, or abscesses)
Alveolar osteitis (complication of wound healing following extraction of a tooth)
Cerebral atrophy (decrement in size of brain)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Decreased activity
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Disease progression
Dysgeusia (disorder of the sense of taste)

What are the common drug interactions of Promethazine W/ Codeine and Dilaudid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Cholecystitis (infection of gallbladder)
Hypertension (high blood pressure)
Influenza like illness
Insomnia (sleeplessness)
Urinary tract infection
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiomegaly (increased size of heart than normal)
Cardiomyopathy (weakening of the heart muscle)

30-39:

n/a

40-49:

n/a

50-59:

Oral disorder (mouth disease)
Spinal cord disorder (disease of spinal cord)
Dental caries
Osteonecrosis (death of bone)
Swelling face
Tooth abscess (pus formation in tooth)
Haematuria (presence of blood in urine)
Sinus disorder (disease of sinus)
Anaemia (lack of blood)
Cyst (a closed sac)

60+:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Chorea (abnormal involuntary movement disorder)
Cogwheel rigidity (tension in a muscle which gives way in little jerks when the muscle is stretched)
Confusional state
Cystitis (inflammation of the wall of the bladder)
Diarrhoea
Dyskinesia (abnormality or impairment of voluntary movement)
Dysphonia (speech disorder attributable to a disorder of phonation)
Ear pain

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 9 people, 50.00%
Peripartum Cardiomyopathy (deterioration in cardiac function presenting typically between the last month of pregnancy and up to five months postpartum): 2 people, 11.11%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 5.56%
Headache (pain in head): 1 person, 5.56%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.56%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 5.56%
Cancer Pain: 1 person, 5.56%
Birth Control: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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