1. Home
  2. Analysis
  3. Promethazine
  4. Abreva

Promethazine and Abreva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Abreva (docosanol). Common drug interactions include back pain among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Abreva. It is created by eHealthMe based on reports of 8 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Abreva?

Abreva has active ingredients of docosanol. It is often used in herpes labialis (oral herpes simplex). eHealthMe is studying from 17,071 Abreva users. Check the latest studies of Abreva.

On Apr, 12, 2026

8 people who take Promethazine and Abreva together, and have interactions are studied.

Promethazine and Abreva drug interactions.

What are the common drug interactions of Promethazine and Abreva, by gender? *:

female:

  1. Back pain
  2. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
  3. Chills (felling of cold)
  4. Constipation
  5. Contusion (a type of hematoma of tissue in which capillaries)
  6. Diarrhoea
  7. Dizziness
  8. Drug hypersensitivity
  9. Dry skin
  10. Dysphagia (a condition in which swallowing is difficult or painful)

male:

  1. Dehydration (dryness resulting from the removal of water)
  2. Drug dependence
  3. Hypersensitivity
  4. Overdose
  5. Poor quality sleep

What are the common drug interactions of Promethazine and Abreva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Dehydration (dryness resulting from the removal of water)
  2. Hypersensitivity
  3. Poor quality sleep

40-49:

n/a

50-59:

  1. Intestinal obstruction
  2. Weight decreased
  3. Chronic kidney disease
  4. Decreased appetite
  5. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  6. Renal failure (kidney dysfunction)
  7. Abdominal discomfort
  8. Abdominal pain
  9. Anaphylactic reaction (serious allergic reaction)
  10. Arthralgia (joint pain)

60+:

  1. Abdominal discomfort
  2. Abdominal pain
  3. Constipation
  4. Contusion (a type of hematoma of tissue in which capillaries)
  5. Diarrhoea
  6. Dizziness
  7. Drug hypersensitivity
  8. Drug intolerance (drug sensitivity)
  9. Dry skin
  10. Dysphagia (a condition in which swallowing is difficult or painful)

* Approximation only. Some reports may have incomplete information.

Do you take Promethazine and Abreva?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Promethazine and Abreva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Promethazine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Abreva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Promethazine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Abreva and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on promethazine hydrochloride and docosanol (the active ingredients of Promethazine and Abreva, respectively), and Promethazine and Abreva (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.