Promethazine and Accolate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Accolate (zafirlukast). Common drug interactions include hypertension among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Accolate. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Accolate?

Accolate has active ingredients of zafirlukast. It is often used in asthma. eHealthMe is studying from 4,220 Accolate users. Check the latest studies of Accolate.

On Jul, 09, 2026

16 people who take Promethazine and Accolate together, and have interactions are studied.

Promethazine and Accolate drug interactions.

What are the common drug interactions of Promethazine and Accolate, by gender? *:

female:

Hypertension (high blood pressure)
Insomnia (sleeplessness)
Memory impairment
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteoporosis (bones weak and more likely to break)
Rash
Abdominal pain
Abdominal pain upper
Acne (skin problems that cause pimples)
Activities of daily living impaired

male:

Chronic kidney disease
Renal failure (kidney dysfunction)

What are the common drug interactions of Promethazine and Accolate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Agitation (state of anxiety or nervous excitement)
Anger
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Insomnia (sleeplessness)
Osteoporosis (bones weak and more likely to break)
Pain

50-59:

Pyrexia (fever)
Rash
Renal failure (kidney dysfunction)
Swelling
Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Forced expiratory volume increased (increased lung expired air volume)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Pruritus (severe itching of the skin)

60+:

Cataract (clouding of the lens inside the eye)
Dry mouth
Dysphonia (speech disorder attributable to a disorder of phonation)
Memory impairment
Pancreatic carcinoma (pancreatic cancer)

What are the existing conditions these people have? *

Pain: 6 people, 37.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 31.25%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 18.75%
Rickets (softening of bones): 3 people, 18.75%
Stable Angina (a constant chest pain): 3 people, 18.75%
Inflammation: 3 people, 18.75%
Hypersensitivity: 3 people, 18.75%
Immunodeficiency Common Variable: 2 people, 12.50%
Fungal Infection: 2 people, 12.50%
Neuropathy Peripheral (surface nerve damage): 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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